Cannata Jenna N, Rouge Jessica L
Department of Chemistry, University of Connecticut, Storrs, CT, USA.
Methods Mol Biol. 2025;2902:55-67. doi: 10.1007/978-1-0716-4402-7_4.
Spherical nucleic acids (SNAs) offer intriguing properties for cellular uptake and stability. A novel SNA-like structure known as the nucleic acid nanocapsule (NAN) combines the benefits of SNAs with the added properties of nucleic acid functionalization and drug cargo release. Herein, we will discuss various ways NANs can be adapted to allow for gene targeting via the delivery of nucleic acids, as well as the delivery of small molecule drugs for combination therapies.
球形核酸（SNA）在细胞摄取和稳定性方面具有引人关注的特性。一种名为核酸纳米胶囊（NAN）的新型类SNA结构，将SNA的优势与核酸功能化及药物载体释放的附加特性相结合。在此，我们将讨论使NAN能够通过核酸递送实现基因靶向以及递送小分子药物用于联合治疗的各种方法。
