Yasuda H, Kikkawa R, Hatanaka I, Kobayashi N, Taniguchi Y, Shigeta Y
Acta Pathol Jpn. 1985 Jan;35(1):1-8. doi: 10.1111/j.1440-1827.1985.tb02201.x.
In an attempt to evaluate the morphological abnormalities of dermal non-myelinated nerve fibers of diabetics and elucidate the pathogenesis of diabetic peripheral neuropathy, the terminal part of peripheral nerve in the upper dermis was observed on electron microscopy using skin samples biopsied in 10 diabetics with symptomatic neuropathy and 6 age-matched controls. In diabetics, the density of nerve fibers was significantly lower than in controls. In addition, swelling, lytic change and vacuolation in the axon, multiplication of basement membrane of the Schwann cell and Schwann cell cluster devoid of axon were more frequently observed in diabetics. The Schwann cell did not show significant structural alterations. These findings suggest that the axon is primarily involved, at least in the terminal region of nerve fiber, in diabetic peripheral neuropathy. It is also concluded that the skin biopsy technique is harmless, cosmetically not troublesome and might be beneficial for studying peripheral neuropathies including diabetic neuropathy.
为了评估糖尿病患者真皮无髓神经纤维的形态异常并阐明糖尿病性周围神经病变的发病机制，我们使用从10例有症状神经病变的糖尿病患者和6例年龄匹配的对照者身上获取的皮肤活检样本，通过电子显微镜观察了上真皮层周围神经的终末部分。在糖尿病患者中，神经纤维密度显著低于对照组。此外，在糖尿病患者中更频繁地观察到轴突肿胀、溶解变化和空泡形成，雪旺细胞基底膜增生以及无轴突的雪旺细胞簇。雪旺细胞未显示出明显的结构改变。这些发现表明，至少在神经纤维的终末区域，轴突在糖尿病性周围神经病变中起主要作用。还得出结论，皮肤活检技术无害，在美容方面不麻烦，可能有助于研究包括糖尿病性神经病变在内的周围神经病变。
