产后急性胰腺炎所致感染性休克:一例报告及文献复习

Septic shock caused by postpartum acute pancreatitis, a case report and literature review.

作者信息

Delavari Changiz, Ghadimi Delaram J, Taheri Maryam, Kumar Harsh, Ebrahimi Pouya, Nasrollahizadeh Amir, Javankiani Sepide

机构信息

Department of Plastic Surgery, Imam Khomeini Hospital of Tehran, Tehran University of Medical Sciences, Tehran, Iran.

School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Int J Emerg Med. 2025 Mar 3;18(1):39. doi: 10.1186/s12245-025-00862-y.

Abstract

INTRODUCTION

Postpartum acute pancreatitis (PAP) is a rare but potentially life-threatening condition that can occur following childbirth. The incidence of PAP is estimated to be between 1 in 1,000 and 1 in 10,000 deliveries, with a significant proportion of cases linked to biliary causes, particularly gallstones and biliary sludge. Prompt diagnosis and comprehensive management are essential to prevent severe complications such as septic shock and peritonitis.

CASE PRESENTATION

We report the case of a 25-year-old white woman who presented with severe abdominal pain and septic shock 18 days after a cesarean section. Initial management included aggressive fluid resuscitation, broad-spectrum antibiotics, and pain control. Diagnostic imaging and laboratory tests confirmed the presence of biliary obstruction due to gallstones and biliary sludge, leading to acute pancreatitis. An endoscopic retrograde cholangiopancreatography (ERCP) was performed to remove the biliary obstructions, followed by a laparoscopic cholecystectomy to prevent recurrence.

DISCUSSION

PAP, while rare, poses significant risks and can lead to serious side effects such as septic shock. Early diagnosis by laboratory workup and imaging is essential. In this instance, gallstones and biliary sludge were found to be the culprit, requiring cholecystectomy and ERCP. ERCP was effective in this patient, despite its controversy in septic patients. The effective management of PAP requires a multidisciplinary approach involving obstetricians, gastroenterologists, surgeons, and critical care specialists.

CONCLUSION

PAP must be identified and treated as soon as possible. Bile obstruction is a common problem that necessitates prompt imaging and, if necessary, endoscopic or surgical intervention. Delays can be fatal; timing is crucial. To prevent deadly consequences, doctors must be extremely suspicious of postpartum patients presenting with abdominal pain.

摘要

引言

产后急性胰腺炎(PAP)是一种罕见但可能危及生命的疾病,可发生在分娩后。PAP的发病率估计为每1000至10000例分娩中有1例,相当一部分病例与胆道原因有关,特别是胆结石和胆泥。及时诊断和综合管理对于预防严重并发症如感染性休克和腹膜炎至关重要。

病例报告

我们报告一例25岁白人女性病例,她在剖宫产术后18天出现严重腹痛和感染性休克。初始治疗包括积极的液体复苏、广谱抗生素和疼痛控制。诊断性影像学检查和实验室检查证实存在由胆结石和胆泥导致的胆道梗阻,进而引发急性胰腺炎。进行了内镜逆行胰胆管造影(ERCP)以解除胆道梗阻,随后进行了腹腔镜胆囊切除术以防止复发。

讨论

PAP虽然罕见,但存在重大风险,可导致严重的副作用,如感染性休克。通过实验室检查和影像学进行早期诊断至关重要。在该病例中,发现胆结石和胆泥是病因,需要进行胆囊切除术和ERCP。尽管ERCP在感染患者中存在争议,但在该患者中是有效的。PAP的有效管理需要多学科方法,涉及产科医生、胃肠病学家、外科医生和重症监护专家。

结论

必须尽快识别和治疗PAP。胆道梗阻是一个常见问题,需要及时进行影像学检查,必要时进行内镜或手术干预。延误可能是致命的;时机至关重要。为防止致命后果,医生必须对出现腹痛的产后患者高度怀疑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3212/11874403/709c4d03a5da/12245_2025_862_Fig1_HTML.jpg

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