犬常见内分泌疾病诊断时的血清胆固醇紊乱：一项回顾性研究。

Serum cholesterol disturbances in dogs with common endocrinopathies at the time of diagnosis: a retrospective study.

作者信息

Huang WeiChun, Paulin Mathieu Victor, Snead Elisabeth C R

机构信息

Internal Medicine Department, Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B2, Canada.

出版信息

BMC Vet Res. 2025 Mar 3;21(1):138. doi: 10.1186/s12917-024-04413-0.

BACKGROUND

Although dyslipidemia is commonly reported in dogs, comparative data on the magnitude of serum cholesterol disturbances have not been reported. We aimed to describe the severity of hyper- and hypocholesterolemia in dogs with common endocrinopathies and to evaluate its association with common laboratory parameters. Medical records were reviewed over a decade (2011-2022) for dogs with hypothyroidism, diabetes mellitus (DM), hyperadrenocorticism (HAC), or hypoadrenocorticism (HA), and included signalment, common laboratory and diagnostic imaging parameters, comorbidities, and medications. This retrospective study included 53 dogs with hypothyroidism, 54 with DM, 62 with HAC, and 79 with HA.

RESULTS

Medians [range] of serum cholesterol concentration ([Chol]) for dogs with hypothyroidism, DM, HAC, and HA were 492 [174-1829], 321 [116-928], 309 [151-630], and 112 mg/dL [31-309], and hypercholesterolemia was reported in 91%, 85%, 81%, and 9% for each disorder, respectively. Median [Chol] was significantly higher in hypothyroid dogs with a serum thyroxine concentration < 0.47 (A = 607) vs. ≥0.47 ug/dL (B = 324 mg/dL) (B-A = -299 mg/dL; 95.21% CI of difference = [-433; -166]; p < .0001), and significantly lower in HAC dogs with serum ALP activity < 1,000 U/L (A = 275) vs. ≥1,000 (B = 360 mg/dL) (B-A = + 74 mg/dL; 95.14% CI of difference = [+ 25; +121], p = .006). Comparison among all studied endocrinopathies showed that median [Chol] was significantly higher in hypothyroid dogs and significantly lower in HA dogs, whereas median [Chol] was similar in HAC and DM dogs.

CONCLUSIONS

Serum cholesterol concentration can serve as a valuable tool to suspect certain canine endocrinopathies.

背景

尽管血脂异常在犬类中普遍存在，但关于血清胆固醇紊乱程度的比较数据尚未见报道。我们旨在描述患有常见内分泌疾病的犬类高胆固醇血症和低胆固醇血症的严重程度，并评估其与常见实验室参数的关联。回顾了过去十年（2011 - 2022年）患有甲状腺功能减退症、糖尿病（DM）、肾上腺皮质功能亢进症（HAC）或肾上腺皮质功能减退症（HA）的犬类的病历，包括信号、常见实验室和诊断成像参数、合并症及用药情况。这项回顾性研究纳入了53只患有甲状腺功能减退症的犬、54只患有糖尿病的犬、62只患有肾上腺皮质功能亢进症的犬和79只患有肾上腺皮质功能减退症的犬。

结果

患有甲状腺功能减退症、糖尿病、肾上腺皮质功能亢进症和肾上腺皮质功能减退症的犬类血清胆固醇浓度（[Chol]）中位数[范围]分别为492[174 - 1829]、321[116 - 928]、309[151 - 630]和112mg/dL[31 - 309]，每种疾病中高胆固醇血症的报告发生率分别为91%、85%、81%和9%。血清甲状腺素浓度<0.47（A = 607）的甲状腺功能减退犬的[Chol]中位数显著高于≥0.47μg/dL（B = 324mg/dL）的犬（B - A = -299mg/dL；差异的95.21%置信区间 = [-433；-166]；p <.0001），血清碱性磷酸酶活性<1,000 U/L（A = 275）的肾上腺皮质功能亢进症犬的[Chol]中位数显著低于≥1,000（B = 360mg/dL）的犬（B - A = +74mg/dL；差异的95.14%置信区间 = [+25；+121]，p =.006）。所有研究的内分泌疾病之间的比较表明，甲状腺功能减退犬的[Chol]中位数显著更高，肾上腺皮质功能减退症犬的[Chol]中位数显著更低，而肾上腺皮质功能亢进症和糖尿病犬的[Chol]中位数相似。