Wei Xing, Li Siqi, Yue Wenwen, Zhang Zhipeng, Wei Jing, Wang Liqi, Hu Ben, Long Nv, Li Chao, Hou Bingmei, Feng Jun, Luo Chunmiao
Department of Cardiology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, 230011, China.
The Fifth Clinical School of Medicine, Anhui Medical University, Hefei, Anhui, 230032, China.
BMC Public Health. 2025 Mar 3;25(1):851. doi: 10.1186/s12889-025-22030-w.
Previous studies have shown a positive association between sedentary behavior (SB) and metabolic syndrome (MetS), but no studies have assessed the mediating effect of depressive symptoms in this process.
Participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) were included. Multiple logistic regression analyses and restricted cubic splines (RCSs) were adopted to assess the correlations among SB duration, depressed mood and MetS. A mediation effect model was constructed to analyze whether there was a mediating effect of depressed mood on the relationship between SB duration and MetS.
This study included 15,944 adults (7,268 patients with MetS in total). We identified high SB duration as an independent risk factor for MetS in a regression model adjusted for relevant confounders (odds ratio (OR) = 1.29, 95% CI [1.08, 1.53]). RCS analysis revealed a nonlinear relationship between SB duration and MetS. The mediation effect analysis revealed that depressive symptoms accounted for 6.70% of the mediation effect between SB duration and MetS. Depressive symptoms were also partially mediated in the analyses with MetS subcomponents.
SB is closely associated with MetS, and this association is not only caused by SB itself but also partially mediated by depressive symptoms.
先前的研究表明久坐行为（SB）与代谢综合征（MetS）之间存在正相关，但尚无研究评估抑郁症状在此过程中的中介作用。
纳入2007 - 2018年美国国家健康与营养检查调查（NHANES）的参与者。采用多元逻辑回归分析和受限立方样条（RCS）来评估SB时长、抑郁情绪与MetS之间的相关性。构建中介效应模型以分析抑郁情绪在SB时长与MetS之间的关系中是否存在中介作用。
本研究纳入了15944名成年人（总共7268名患有MetS的患者）。在调整了相关混杂因素的回归模型中，我们将高SB时长确定为MetS的独立危险因素（优势比（OR）= 1.29，95%置信区间[1.08, 1.53]）。RCS分析揭示了SB时长与MetS之间的非线性关系。中介效应分析表明，抑郁症状在SB时长与MetS之间的中介效应中占6.70%。在对MetS子成分的分析中，抑郁症状也起到了部分中介作用。
SB与MetS密切相关，这种关联不仅由SB本身引起，还部分由抑郁症状介导。
