Blokland L, de Kuijper-Timmermans E, de Kuijper M, Gooijer K, Harsevoort G J, Zillikens M C, Appelman-Dijkstra N M, Janus G J M, Kalaykova S
Vogellanden Center of Rehabilitation Medicine & Special Care in Dentistry, Zwolle, the Netherlands.
Department of Dentistry, Radboud University Medical Center, Nijmegen, the Netherlands.
Oral Dis. 2025 Jun;31(6):1909-1921. doi: 10.1111/odi.15280. Epub 2025 Mar 3.
This study investigated self-reported symptoms of temporomandibular disorders, mandibular functional impairment, and obstructive sleep apnea among Dutch adults with Osteogenesis Imperfecta.
A cross-sectional online survey was distributed among Dutch adults with Osteogenesis Imperfecta. Possible risk factors for self-reported temporomandibular disorders (3Q/TMD; DC/TMD), mandibular impairments (Mandibular Function Impairment Questionnaire), and obstructive sleep apnea (STOP-Bang) were explored using univariate and multiple regression analyses.
31% of 155 respondents reported temporomandibular disorder symptoms and 40.0% and 5.2% moderate and severe mandibular function impairment, respectively. Intermediate and severe risk for obstructive sleep apnea were reported by 16.1% and 14.8%, respectively. Female gender and Osteogenesis Imperfecta type III were independently associated with the presence of self-reported temporomandibular disorders. Osteogenesis Imperfecta type III, missing teeth, and self-reported temporomandibular disorders were independently associated with impaired mandibular function. Higher age, male gender, and bisphonate use were independently associated with a higher risk for positive screening for obstructive sleep apnea.
A substantial proportion of Dutch adults with Osteogenesis Imperfecta reported symptoms indicative of temporomandibular disorders, mandibular function impairment, and higher risk for obstructive sleep apnea. Especially Osteogenesis Imperfecta type III patients are at risk for self-reported temporomandibular disorders and hampered mandibular function.
本研究调查了荷兰成骨不全症患者自我报告的颞下颌关节紊乱症状、下颌功能障碍和阻塞性睡眠呼吸暂停情况。
对荷兰成骨不全症成年患者进行了一项横断面在线调查。使用单因素和多因素回归分析探讨了自我报告的颞下颌关节紊乱（3Q/TMD；DC/TMD）、下颌功能障碍（下颌功能障碍问卷）和阻塞性睡眠呼吸暂停（STOP-Bang）的可能危险因素。
155名受访者中，31%报告有颞下颌关节紊乱症状，分别有40.0%和5.2%存在中度和重度下颌功能障碍。分别有16.1%和14.8%报告存在阻塞性睡眠呼吸暂停的中度和重度风险。女性性别和成骨不全症III型与自我报告的颞下颌关节紊乱独立相关。成骨不全症III型、缺牙和自我报告的颞下颌关节紊乱与下颌功能受损独立相关。年龄较大、男性性别和使用双膦酸盐与阻塞性睡眠呼吸暂停阳性筛查的较高风险独立相关。
相当比例的荷兰成骨不全症成年患者报告有提示颞下颌关节紊乱、下颌功能障碍和阻塞性睡眠呼吸暂停较高风险的症状。特别是成骨不全症III型患者有自我报告的颞下颌关节紊乱和下颌功能受限的风险。
