Wilson R D, Baird P A
Am J Med Genet. 1985 May;21(1):153-69. doi: 10.1002/ajmg.1320210123.
We review the incidence of bilateral and unilateral renal agenesis occurring in more than 625,000 consecutive births in British Columbia from 1952 to 1982. In total, 92 cases of bilateral renal agenesis and 117 cases of unilateral renal agenesis were identified. Congenital anomalies occurring in association with these conditions were also analyzed. The findings of the study support a mechanism in at least a proportion of cases of a primary developmental defect involving multiple systems within the fetus, with oligohydramnios being the result of the syndrome not the cause. Oligohydramnios no doubt contributes to the anomalies of the face, musculoskeletal system, and genitalia. No trends in changing incidence over time were identified.
我们回顾了1952年至1982年在不列颠哥伦比亚省连续超过62.5万例出生中双侧和单侧肾发育不全的发生率。总共确定了92例双侧肾发育不全和117例单侧肾发育不全病例。还分析了与这些情况相关的先天性异常。该研究结果支持至少在一部分病例中存在一种涉及胎儿多个系统的原发性发育缺陷机制，羊水过少是该综合征的结果而非原因。羊水过少无疑会导致面部、肌肉骨骼系统和生殖器的异常。未发现发病率随时间变化的趋势。
