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细胞外囊泡在ⅢA型慢性前列腺炎发病机制中的研究进展

Research progress of extracellular vesicles in the pathogenesis of type IIIA chronic prostatitis.

作者信息

Cheng Le, Luo Peiyue, Li Wei, Chen Qi, Gan Lifeng, Zhang Fangtao, Zheng Liying, Qian Biao

机构信息

The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China.

Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

出版信息

Front Immunol. 2025 Feb 17;16:1496055. doi: 10.3389/fimmu.2025.1496055. eCollection 2025.

Abstract

Chronic prostatitis is a prevalent urological condition that significantly impacts patients' quality of life. Advances in the study of Extracellular Vesicles (EV) have revealed their close involvement in the pathogenesis of prostatitis. This paper reviews the progress in understanding the role of EV in the pathogenesis of chronic prostatitis type IIIA, particularly their involvement in inflammatory responses, cell signaling, and interactions with immune cells. Additionally, it explores the potential applications of EV as drug delivery vehicles, including the targeted delivery of anti-inflammatory agents and immunomodulators, and highlights the challenges associated with developing exosome-based therapeutic strategies. In-depth research on EV holds promise for offering new insights into the diagnosis and treatment of inflammatory diseases.

摘要

慢性前列腺炎是一种常见的泌尿系统疾病,严重影响患者的生活质量。细胞外囊泡(EV)研究的进展表明它们与前列腺炎的发病机制密切相关。本文综述了对EV在ⅢA型慢性前列腺炎发病机制中作用的认识进展,特别是它们在炎症反应、细胞信号传导以及与免疫细胞相互作用中的作用。此外,还探讨了EV作为药物递送载体的潜在应用,包括抗炎剂和免疫调节剂的靶向递送,并强调了开发基于外泌体的治疗策略所面临的挑战。对EV的深入研究有望为炎症性疾病的诊断和治疗提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf0/11873842/8041d89c2b68/fimmu-16-1496055-g001.jpg

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