Edelstone D I, Peticca B B, Goldblum L J
Am J Obstet Gynecol. 1985 Jun 1;152(3):351-8. doi: 10.1016/s0002-9378(85)80226-x.
In 11 chronically catheterized fetal lambs (123 +/- 6, mean +/- SD, days of gestation; term = 147 days), we measured fetal oxygen delivery and oxygen consumption before and during reductions in umbilical blood flow (Qumb). Qumb was reduced by inflation of a balloon occluder located just proximal to the origin of the common umbilical artery. Measurements were made while the unanesthetized maternal sheep received either room air or 100% oxygen to breathe. In oxygen-treated fetuses, oxygen concentrations in umbilical venous blood (Cuvo2) and arterial blood (Cao2) were increased over a wide range of Qumb when compared with those of room air-treated fetuses. Because of these responses, fetal oxygen delivery (Do2 = Qumb X Cuvo2) and oxygen consumption [Vo2 = Qumb(Cuvo2-Cao2)] were greater in oxygen-treated fetuses than in room air-treated fetuses during episodes of reduced Qumb. In oxygen-treated fetuses, Vo2 decreased from normal levels only when Qumb was less than or equal to 75 ml/min/kg of fetus, whereas in room air-treated fetuses Vo2 decreased at Qumb less than or equal to 150 ml/min/kg. Our data indicate that oxygen administration to the pregnant sheep increases oxygen delivery to the fetus during times of reduced umbilical perfusion and that this supplemental oxygen supply provides an oxygen reserve with which the fetus can maintain oxidative metabolism. These data may be relevant to those clinical conditions, such as umbilical cord compression in labor, that are associated with reductions in umbilical blood flow.
在11只长期插管的胎羊中（妊娠天数为123±6天，平均±标准差；足月为147天），我们在脐血流量（Qumb）减少之前和期间测量了胎儿的氧输送和氧消耗。通过向位于脐动脉起始部近端的球囊封堵器充气来减少Qumb。在未麻醉的母羊吸入室内空气或100%氧气时进行测量。与吸入室内空气的胎儿相比，在氧气处理的胎儿中，在较宽的Qumb范围内，脐静脉血（Cuvo2）和动脉血（Cao2）中的氧浓度均升高。由于这些反应，在Qumb减少期间，氧气处理的胎儿的胎儿氧输送（Do2 = Qumb×Cuvo2）和氧消耗[Vo2 = Qumb（Cuvo2 - Cao2）]比吸入室内空气的胎儿更大。在氧气处理的胎儿中，仅当Qumb小于或等于75 ml/min/kg胎儿时，Vo2才从正常水平下降，而在吸入室内空气的胎儿中，当Qumb小于或等于150 ml/min/kg时，Vo2就下降。我们的数据表明，给怀孕母羊吸氧可在脐灌注减少时增加向胎儿的氧输送，并且这种补充氧气供应提供了一种氧储备，胎儿可利用该储备维持氧化代谢。这些数据可能与那些与脐血流量减少相关的临床情况有关，例如分娩时的脐带受压。
