Cines D B, Cassileth P A, Kiss J E
Ann Intern Med. 1985 Jul;103(1):58-60. doi: 10.7326/0003-4819-103-1-58.
Platelet-associated IgG was markedly elevated in three patients with myelodysplasia and severe thrombocytopenia that had become refractory to platelet transfusions. The patients were treated with danazol because of its efficacy in treating immune thrombocytopenic purpura where platelet destruction is primarily mediated by IgG autoantibodies. After danazol therapy, the platelet counts of each patient rose and clinical bleeding stopped, and a decline in hemolysis was seen in two patients. Danazol probably impeded the peripheral clearance of cells by macrophages; however, a beneficial effect of danazol on hematopoiesis cannot be excluded.
三名骨髓增生异常综合征伴严重血小板减少且对血小板输注难治的患者，其血小板相关IgG显著升高。这些患者因达那唑在治疗免疫性血小板减少性紫癜（血小板破坏主要由IgG自身抗体介导）方面的疗效而接受达那唑治疗。达那唑治疗后，每位患者的血小板计数上升，临床出血停止，两名患者的溶血有所减轻。达那唑可能阻碍了巨噬细胞对细胞的外周清除；然而，不能排除达那唑对造血有有益作用。
