Guo Huimin, Yuan Huimin, Yu Yanru, Sun Jingwei, Sun Yan, Tang Yang, Zheng Fengjie
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Front Immunol. 2025 Feb 18;16:1489277. doi: 10.3389/fimmu.2025.1489277. eCollection 2025.
Atopic dermatitis (AD) is a chronic relapsing disease with complex pathogenesis. Among them, inflammation is one of the primary pathogenesis of AD. AD is characterized by infiltration of lymphocytes into the skin's dermis, and the skin homing of lymphocytes plays an essential role in the recurrence of AD. Currently, there is more and more evidence to support this view. This article reviews the relevant role of T lymphocyte skin-homing-related molecules in the recurrence of AD to provide a reference for the cure of AD.
特应性皮炎(AD)是一种发病机制复杂的慢性复发性疾病。其中,炎症是AD的主要发病机制之一。AD的特征是淋巴细胞浸润至皮肤真皮层,淋巴细胞归巢至皮肤在AD复发中起重要作用。目前,越来越多的证据支持这一观点。本文综述T淋巴细胞皮肤归巢相关分子在AD复发中的相关作用,为AD的治疗提供参考。