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皮肤归巢T细胞在特应性皮炎复发中的作用：综述

Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review.

作者信息

Guo Huimin, Yuan Huimin, Yu Yanru, Sun Jingwei, Sun Yan, Tang Yang, Zheng Fengjie

机构信息

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

出版信息

Front Immunol. 2025 Feb 18;16:1489277. doi: 10.3389/fimmu.2025.1489277. eCollection 2025.

DOI:10.3389/fimmu.2025.1489277
PMID:40040698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11876967/
Abstract

Atopic dermatitis (AD) is a chronic relapsing disease with complex pathogenesis. Among them, inflammation is one of the primary pathogenesis of AD. AD is characterized by infiltration of lymphocytes into the skin's dermis, and the skin homing of lymphocytes plays an essential role in the recurrence of AD. Currently, there is more and more evidence to support this view. This article reviews the relevant role of T lymphocyte skin-homing-related molecules in the recurrence of AD to provide a reference for the cure of AD.

摘要

特应性皮炎（AD）是一种发病机制复杂的慢性复发性疾病。其中，炎症是AD的主要发病机制之一。AD的特征是淋巴细胞浸润至皮肤真皮层，淋巴细胞归巢至皮肤在AD复发中起重要作用。目前，越来越多的证据支持这一观点。本文综述T淋巴细胞皮肤归巢相关分子在AD复发中的相关作用，为AD的治疗提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae5/11876967/a3dcfc578c24/fimmu-16-1489277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae5/11876967/a3dcfc578c24/fimmu-16-1489277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae5/11876967/a3dcfc578c24/fimmu-16-1489277-g001.jpg

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The role of OX40 ligand/OX40 axis signalling in atopic dermatitis.OX40 配体/OX40 轴信号在特应性皮炎中的作用。
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2
Patients' and caregivers' perspectives of the atopic dermatitis journey.患者和照护者的特应性皮炎病程体验。
J Dermatolog Treat. 2024 Dec;35(1):2315145. doi: 10.1080/09546634.2024.2315145. Epub 2024 Feb 22.
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Randomized double-blind placebo-controlled cosmetic trial of a topical first-in-class Neutraligand targeting the chemokine TARC/CCL17 in mild-to-moderate atopic dermatitis.
一项针对轻度至中度特应性皮炎的局部用一流趋化因子TARC/CCL17靶向中性配体的随机双盲安慰剂对照化妆品试验。
Int J Cosmet Sci. 2024 Jun;46(3):468-477. doi: 10.1111/ics.12948. Epub 2024 Feb 7.
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Outlining the skin-homing and circulating CLANK cells in patients with severe atopic dermatitis.概述严重特应性皮炎患者的皮肤归巢和循环 CLANK 细胞。
Sci Rep. 2024 Feb 1;14(1):2663. doi: 10.1038/s41598-024-53224-8.
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Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study.口服 CCR4 拮抗剂 RPT193 治疗特应性皮炎的临床和分子效应：一项 1 期研究。
Allergy. 2024 Apr;79(4):924-936. doi: 10.1111/all.15949. Epub 2023 Nov 20.
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Neutrophil recruitment by CD4 tissue-resident memory T cells induces chronic recurrent inflammation in atopic dermatitis.CD4 组织驻留记忆 T 细胞募集中性粒细胞导致特应性皮炎的慢性复发性炎症。
Clin Immunol. 2023 Nov;256:109805. doi: 10.1016/j.clim.2023.109805. Epub 2023 Oct 11.
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