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CAR-T cell therapy based on a TCR mimic nanobody targeting an intracellular antigen for solid cancers.

作者信息

Lin Qingqing, Jin Shi, Wang Mingjun

机构信息

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen International Biological Valley-Life Science Industrial Park, Dapeng New District, Shenzhen, China.

Shenzhen Innovation Immunotechnology Co., Ltd., Shenzhen International Biological Valley-Life Science Industrial Park, Dapeng New District, Shenzhen, China.

出版信息

Mol Ther Oncol. 2025 Feb 18;33(1):200948. doi: 10.1016/j.omton.2025.200948. eCollection 2025 Mar 20.

DOI:10.1016/j.omton.2025.200948
PMID:40041799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11876872/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad5/11876872/4632b1eea741/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad5/11876872/4632b1eea741/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad5/11876872/4632b1eea741/gr1.jpg

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本文引用的文献

1
Unlocking Intracellular Oncology Targets: The Unique Role of Antibody-Based T-Cell Receptor Mimic (TCRm) Therapeutics in T-Cell Engagers (TCEs) and Antibody-Drug Conjugates (ADCs).解锁细胞内肿瘤靶点：基于抗体的T细胞受体模拟物（TCRm）疗法在T细胞衔接器（TCE）和抗体药物偶联物（ADC）中的独特作用。
Cancers (Basel). 2024 Nov 8;16(22):3776. doi: 10.3390/cancers16223776.
2
CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer.基于靶向人乳头瘤病毒16型E6的T细胞受体模拟纳米抗体的嵌合抗原受体T细胞对宫颈癌具有抗肿瘤活性。
Mol Ther Oncol. 2024 Oct 9;32(4):200892. doi: 10.1016/j.omton.2024.200892. eCollection 2024 Dec 19.
3
From bench to bedside: the history and progress of CAR T cell therapy.
从实验室到临床：嵌合抗原受体 T 细胞疗法的历史与进展。
Front Immunol. 2023 May 15;14:1188049. doi: 10.3389/fimmu.2023.1188049. eCollection 2023.
4
Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.鉴定和承诺一种 TCR 模拟抗体用于肝癌的癌症免疫治疗。
Sci Rep. 2022 Jul 15;12(1):12068. doi: 10.1038/s41598-022-15946-5.
5
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy.开发针对 NY-ESO-1/HLA-A2 的 TCR 样抗体和嵌合抗原受体用于癌症免疫治疗。
J Immunother Cancer. 2022 Mar;10(3). doi: 10.1136/jitc-2021-004035.
6
A TCR mimic monoclonal antibody for the HPV-16 E7-epitope p11-19/HLA-A*02:01 complex.一种针对 HPV-16 E7-表位 p11-19/HLA-A*02:01 复合物的 TCR 模拟单克隆抗体。
PLoS One. 2022 Mar 17;17(3):e0265534. doi: 10.1371/journal.pone.0265534. eCollection 2022.
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Caplacizumab in adult patients with acquired thrombotic thrombocytopenic purpura.卡泊单抗用于成年获得性血栓性血小板减少性紫癜患者。
Ther Adv Hematol. 2020 Feb 7;11:2040620720902904. doi: 10.1177/2040620720902904. eCollection 2020.
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Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen.针对表达突变型 p53 的肿瘤，使用针对野生型抗原的 T 细胞受体样抗体。
Nat Commun. 2019 Nov 26;10(1):5382. doi: 10.1038/s41467-019-13305-z.