Takeichi N
Gan To Kagaku Ryoho. 1985 Jun;12(6):1210-21.
It is still difficult to control metastasis of cancers, despite advances in surgery and radio-therapy for primary lesions of cancers. The prevention of cancer metastasis is therefore a major target of cancer research. In order to analyse the mechanism of tumor metastasis, several in vivo and in vitro assay systems have been established and the effects of host and tumor factors on formation of tumor metastasis have been studied. It is known that specific immunity mediated by T cells and natural resistance mediated by macrophages and natural killer cells play a significant role in host defense mechanisms against tumor metastasis. I describe here my study of the effect of surgical operation of primary tumors on metastasis and of the suppression of tumor metastasis by activated natural host defense using an experimental model of spontaneous metastasis in spontaneously hypertensive rats (SHR).
尽管针对癌症原发灶的手术和放疗取得了进展，但控制癌症转移仍然困难。因此，预防癌症转移是癌症研究的主要目标。为了分析肿瘤转移的机制，已经建立了几种体内和体外检测系统，并研究了宿主和肿瘤因素对肿瘤转移形成的影响。众所周知，T细胞介导的特异性免疫以及巨噬细胞和自然杀伤细胞介导的天然抵抗力在宿主对抗肿瘤转移的防御机制中发挥着重要作用。在此，我描述了我利用自发性高血压大鼠（SHR）自发性转移的实验模型，对原发性肿瘤手术操作对转移的影响以及激活天然宿主防御对肿瘤转移的抑制作用的研究。
