Solmi Marco, Basadonne Ilaria, Bodini Luca, Rosenbaum Simon, Schuch Felipe B, Smith Lee, Stubbs Brendon, Firth Joseph, Vancampfort Davy, Ashdown-Franks Garcia, Carvalho Andre F, Radua Joaquim, Fusar-Poli Laura, Correll Christoph U, Fusar-Poli Paolo
Department of Psychiatry, University of Ottawa, Ottawa, Canada; Regional Centre for the Treatment of Eating Disorders and on Track: the Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ottawa, Canada; Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa, Ottawa, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.
Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.
J Psychiatr Res. 2025 Apr;184:91-101. doi: 10.1016/j.jpsychires.2025.02.024. Epub 2025 Feb 18.
Exercise is beneficial for mental health in general, but no review has systematically assessed its potential transdiagnostic nature, i.e. whether it is beneficial across specific disorders. We performed a systematic umbrella review of meta-analyses of randomized controlled trials (RCTs) of exercise in participants with mental disorders defined according to the International Classification of Diseases (ICD) or the Diagnostic and Statistical Manual of Mental Disorders (DSM), assessing exercise's transdiagnostic nature with TRANSD criteria, including eight meta-analyses (six included in the TRANSD meta-analysis), encompassing 99 RCTs (n = 5,656) across 11 disorders. Moderate/vigorous aerobic exercise was an effective transdiagnostic intervention for disease-specific primary symptoms across 11 disorders (recurrent depressive disorder, social phobia, panic disorder, generalized anxiety disorder, post-traumatic stress disorder, brief psychotic disorder, schizophrenia, schizoaffective disorder, delusional disorder, schizophreniform disorder, attention-deficit/hyperactivity disorder) and four spectra (depressive disorders, anxiety disorders, schizophrenia-spectrum disorders, neurodevelopmental disorders) with a medium effect size (SMD = -0.67, 95%CI = -0.84, -0.50). Moderate/vigorous aerobic exercise also improved cognition across two disorders (schizophrenia, attention-deficit/hyperactivity disorder) and two spectra (schizophrenia-spectrum disorders, neurodevelopmental disorders), with a large effect size (SMD = 0.92, 95%CI = 0.52, 1.33). According to TRANSD criteria, moderate/vigorous aerobic exercise is a transdiagnostic intervention to improve disease-specific primary symptoms of 11 mental disorders, and cognition in two mental disorders.
一般而言，运动对心理健康有益，但尚无综述系统评估其潜在的跨诊断性质，即它是否对特定疾病均有益。我们对根据国际疾病分类（ICD）或精神疾病诊断与统计手册（DSM）定义的精神障碍患者进行运动的随机对照试验（RCT）的荟萃分析进行了系统的综合综述，采用跨诊断标准（TRANSD）评估运动的跨诊断性质，包括八项荟萃分析（六项纳入TRANSD荟萃分析），涵盖11种疾病的99项RCT（n = 5656）。中等强度/剧烈有氧运动是一种有效的跨诊断干预措施，可改善11种疾病（复发性抑郁症、社交恐惧症、惊恐障碍、广泛性焦虑障碍、创伤后应激障碍、短暂性精神病性障碍、精神分裂症、分裂情感性障碍、妄想障碍、精神分裂症样障碍、注意力缺陷多动障碍）以及四个谱系（抑郁症谱系障碍、焦虑症谱系障碍、精神分裂症谱系障碍、神经发育障碍）的疾病特异性主要症状，效应量中等（标准化均数差[SMD]= -0.67，95%可信区间[CI]= -0.84，-0.50）。中等强度/剧烈有氧运动还改善了两种疾病（精神分裂症、注意力缺陷多动障碍）以及两个谱系（精神分裂症谱系障碍、神经发育障碍）的认知功能，效应量较大（SMD = 0.92，95%CI = 0.52，1.33）。根据TRANSD标准，中等强度/剧烈有氧运动是一种跨诊断干预措施，可改善11种精神疾病的疾病特异性主要症状以及两种精神疾病的认知功能。
