Long Hairong, Huang Rui, Zhu Shuangjie, Wang Zuhan, Liu Xiaoling, Zhu Zhenjun
School of Biological Science and Food Engineering, Chuzhou University, Chuzhou 239001, Anhui, PR China; College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, Guangxi, PR China.
Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, PR China.
Int J Biol Macromol. 2025 May;306(Pt 3):141663. doi: 10.1016/j.ijbiomac.2025.141663. Epub 2025 Mar 6.
Polysaccharide from Caulerpa lentillifera (CLP) offers preventative health benefits, but its efficacy against hyperlipidaemia and underlying mechanisms still elusive. This investigation assessed CLP's potential to mitigate high-fat diet (HFD)-induced hyperlipidaemia via the gut microbiota-bile acid (BA) axis. In hyperlipidaemic mice, 8 weeks of CLP treatment improved body weight, lipid profiles, and hepatic function, correlating with shifts in BA concentrations. Additionally, CLP not only repaired HFD-induced gut dysbiosis by increasing SCFA-producing bacteria but also positively modulated gut metabolites, including acetic and butyric acids. Spearman's correlation analysis illustrated strong associations between the altered microbes, metabolites, and the expression of genes involved in BA metabolism. Remarkably, CLP significantly influenced BA levels related to hyperlipidaemia, partly by augmenting the population of Parabacteroides and associated butyric acid level. These results indicate that CLP may serve as a functional food to guard against dyslipidaemia through impacting specific gut microbes and metabolites such as Parabacteroides and butyrate, and thus presenting promising therapeutic prospects for diseases associated with BA metabolism.
来自绿藻的多糖（CLP）具有预防健康的益处，但其对高脂血症的疗效及潜在机制仍不明确。本研究评估了CLP通过肠道微生物群-胆汁酸（BA）轴减轻高脂饮食（HFD）诱导的高脂血症的潜力。在高脂血症小鼠中，8周的CLP治疗改善了体重、血脂谱和肝功能，这与BA浓度的变化相关。此外，CLP不仅通过增加产生短链脂肪酸的细菌来修复HFD诱导的肠道生态失调，还对肠道代谢产物产生积极调节作用，包括乙酸和丁酸。Spearman相关性分析表明，微生物、代谢产物的改变与BA代谢相关基因的表达之间存在密切关联。值得注意的是，CLP显著影响与高脂血症相关的BA水平，部分原因是增加了副拟杆菌的数量以及相关的丁酸水平。这些结果表明，CLP可能作为一种功能性食品，通过影响特定的肠道微生物和代谢产物，如副拟杆菌和丁酸盐，来预防血脂异常，从而为与BA代谢相关的疾病提供有前景的治疗前景。
