Witjaksono Latisha E, Schulte Max, Holland Anne E, Wijsenbeek Marlies S, Khor Yet H
Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Faulty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Eur Respir Rev. 2025 Mar 5;34(175). doi: 10.1183/16000617.0212-2023. Print 2025 Jan.
The role of objective cough monitoring systems for assessments in adults with chronic respiratory diseases (CRDs) is unclear. This systematic review aimed to synthesise current literature on frequency of use and characteristics of these systems.
MEDLINE, Embase and CENTRAL were systematically searched to identify relevant literature evaluating cough in adults with CRDs using objective cough monitoring systems. The primary outcomes were utility and characteristics of the systems, with the secondary outcome being usability.
We identified 54 primary studies (4909 patients, with 3364 having idiopathic chronic cough). Included studies were generally of low risk of bias. Objective monitoring systems identified were VitaloJAK (n=19 studies), Leicester Cough Monitor (LCM, n=18), LEOSound (n=2), PulmoTrack (n=2), Hull Automated Cough Counter (HACC, n=1), LifeShirt (n=1), and unnamed devices (n=11). There was limited assessment against manual counting, with low-to-moderate correlation to patient-reported outcome measures for VitaloJAK (p<0.05), LCM (r=0.43-0.78) and unnamed devices (r=0.38-0.40). Test-retest consistency was evaluated in two studies, showing favourable results. There was at least moderate effect size of longitudinal measurement changes to various treatments for VitaloJAK (nine out of 16), LCM (two out of eight), HACC (n=1), LCM and HACC (n=1), PulmoTrack (n=1) and unnamed devices (n=3).
Few studies evaluated the agreement of objective cough monitoring systems against manual counting. Most studies were conducted in patients with idiopathic chronic cough, with the VitaloJAK and LCM being were the most evaluated objective cough monitoring systems. Further evaluation of objective cough monitoring systems is needed for research and clinic application.
客观咳嗽监测系统在慢性呼吸道疾病（CRD）成人患者评估中的作用尚不清楚。本系统评价旨在综合有关这些系统使用频率和特征的现有文献。
系统检索MEDLINE、Embase和CENTRAL，以识别使用客观咳嗽监测系统评估CRD成人咳嗽情况的相关文献。主要结局为系统的实用性和特征，次要结局为易用性。
我们纳入了54项原始研究（4909例患者，其中3364例患有特发性慢性咳嗽）。纳入研究的偏倚风险一般较低。识别出的客观监测系统有VitaloJAK（19项研究）、莱斯特咳嗽监测仪（LCM，18项）、LEOSound（2项）、PulmoTrack（2项）、赫尔自动咳嗽计数器（HACC，1项）、LifeShirt（1项）和未命名设备（11项）。与人工计数相比的评估有限，VitaloJAK（p<0.05）、LCM（r=0.43-0.78）和未命名设备（r=0.38-0.40）与患者报告结局指标的相关性为低到中度。两项研究评估了重测一致性，结果良好。对于VitaloJAK（16项中的9项）、LCM（8项中的2项）、HACC（1项）、LCM和HACC（1项）、PulmoTrack（1项）和未命名设备（3项），纵向测量变化对各种治疗的效应大小至少为中度。
很少有研究评估客观咳嗽监测系统与人工计数的一致性。大多数研究是在特发性慢性咳嗽患者中进行的，VitaloJAK和LCM是评估最多的客观咳嗽监测系统。客观咳嗽监测系统在研究和临床应用中需要进一步评估。
