Gordadze N G, Tsagareli Z G
Arkh Patol. 1985;47(4):27-35.
The protective action of the 2nd type neuroleptanalgesia (NLA) preparations on the damaged myocardium in experimental infarction complicated by cardiogenic shock is documented and analysed. The use of NLA within the first 5 days of the infarction complicated by cardiogenic shock decreased the intensity of the myocardial damage in the zone around the infarction and prevented necrotic changes in teh "extra-infarction" myocardium. Consequently, cardiosclerosis developing after the infarction had a smaller size and at a lesser degree decreased the contractile capacity of the heart muscle and its energy supply. The protective influence of NLA on the myocardium in cardiogenic shock is brought about through the action of the preparations on the various pathogenetic components of shock upon which the size of the myocardial damage depends.
记录并分析了二类神经安定镇痛术（NLA）制剂对实验性梗死合并心源性休克时受损心肌的保护作用。在梗死合并心源性休克的头5天内使用NLA，可降低梗死灶周围心肌损伤的强度，并防止“梗死外”心肌发生坏死性改变。因此，梗死后发生的心肌硬化面积较小，对心肌收缩能力及其能量供应的降低程度也较小。NLA对心源性休克时心肌的保护作用是通过该制剂对休克的各种发病机制成分起作用而实现的，而心肌损伤的大小取决于这些成分。
