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本文引用的文献

1
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury.支链氨基酸分解代谢的激活可预防肾毒性急性肾损伤。
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F152-F163. doi: 10.1152/ajprenal.00260.2024. Epub 2024 Dec 9.
2
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease.慢性肾脏病中炎症与纤维化交叉点上的代谢
Nat Rev Nephrol. 2025 Jan;21(1):39-56. doi: 10.1038/s41581-024-00889-z. Epub 2024 Sep 17.
3
Amino acid metabolism in kidney health and disease.肾脏健康与疾病中的氨基酸代谢。
Nat Rev Nephrol. 2024 Dec;20(12):771-788. doi: 10.1038/s41581-024-00872-8. Epub 2024 Aug 28.
4
Deceased donor kidney function and branched chain amino acid metabolism during ex vivo normothermic perfusion.离体常温灌流过程中供体肾脏功能和支链氨基酸代谢。
Kidney Int. 2024 Oct;106(4):712-722. doi: 10.1016/j.kint.2024.06.026. Epub 2024 Jul 27.
5
The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.BCDK 抑制剂 BT2 是一种化学解偶联剂，可降低线粒体 ROS 产生和从头脂肪生成。
J Biol Chem. 2024 Mar;300(3):105702. doi: 10.1016/j.jbc.2024.105702. Epub 2024 Jan 30.
6
MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease.微小 RNA 介导的支链氨基酸分解代谢减弱促进慢性肾脏病中的铁死亡。
Nat Commun. 2023 Nov 28;14(1):7814. doi: 10.1038/s41467-023-43529-z.
7
Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.Krüppel 样因子 6 介导的支链氨基酸分解代谢缺失导致小鼠和人类的肾脏损伤。
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). doi: 10.1073/pnas.2024414118.
8
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.支链氨基酸的不良代谢作用是由异亮氨酸和缬氨酸介导的。
Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21.
9
NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury.基于 NMR 的血清和尿液代谢组学图谱揭示了实验性脓毒症相关急性肾损伤中线粒体途径的抑制。
Am J Physiol Renal Physiol. 2021 May 1;320(5):F984-F1000. doi: 10.1152/ajprenal.00582.2020. Epub 2021 Apr 12.
10
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection.肾脏生理学与急性肾损伤易感性：对肾脏保护的启示。
Nat Rev Nephrol. 2021 May;17(5):335-349. doi: 10.1038/s41581-021-00394-7. Epub 2021 Feb 5.

Fueling kidney recovery: boosting BCAA metabolism to overcome nephrotoxic AKI.

作者信息

Kapitsinou Pinelopi P

机构信息

Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.

Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.

出版信息

Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F596-F598. doi: 10.1152/ajprenal.00024.2025. Epub 2025 Mar 6.

DOI:10.1152/ajprenal.00024.2025
PMID:40047271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12087460/
Abstract
摘要