Fueling kidney recovery: boosting BCAA metabolism to overcome nephrotoxic AKI.
作者信息
Kapitsinou Pinelopi P
机构信息
Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
出版信息
Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F596-F598. doi: 10.1152/ajprenal.00024.2025. Epub 2025 Mar 6.
Abstract
摘要
相似文献
1
Fueling kidney recovery: boosting BCAA metabolism to overcome nephrotoxic AKI.助力肾脏恢复：增强支链氨基酸代谢以克服肾毒性急性肾损伤
Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F596-F598. doi: 10.1152/ajprenal.00024.2025. Epub 2025 Mar 6.
2
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury.支链氨基酸分解代谢的激活可预防肾毒性急性肾损伤。
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F152-F163. doi: 10.1152/ajprenal.00260.2024. Epub 2024 Dec 9.
3
Acute kidney injury and increasing nephrotoxic-medication exposure in noncritically-ill children.非危重病儿童的急性肾损伤和不断增加的肾毒性药物暴露。
Clin J Am Soc Nephrol. 2011 Apr;6(4):856-63. doi: 10.2215/CJN.08110910. Epub 2011 Jan 6.
4
Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.Krüppel 样因子 6 介导的支链氨基酸分解代谢缺失导致小鼠和人类的肾脏损伤。
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). doi: 10.1073/pnas.2024414118.
5
Acute Kidney Injury in Relation to Nephrotoxic Medication Use Among Critically Ill Children in the Paediatric Intensive Care Unit.儿科重症监护病房中危重症儿童使用肾毒性药物与急性肾损伤的关系
J Pharm Pract. 2025 Feb;38(1):107-114. doi: 10.1177/08971900241273206. Epub 2024 Aug 12.
6
Prediction and Clinically Important Factors of Acute Kidney Injury Non-recovery.急性肾损伤未恢复的预测及临床重要因素
Front Med (Lausanne). 2022 Jan 17;8:789874. doi: 10.3389/fmed.2021.789874. eCollection 2021.
7
Nephrotoxic medications and associated acute kidney injury in hospitalized neonates.住院新生儿的肾毒性药物和相关急性肾损伤。
J Nephrol. 2022 Jul;35(6):1679-1687. doi: 10.1007/s40620-022-01264-6. Epub 2022 Feb 15.
8
Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action): Reduction of Nephrotoxic Medication-Associated Acute Kidney Injury in the Neonatal Intensive Care Unit.婴儿忍者（及时行动消除肾毒性损伤）：减少新生儿重症监护病房中与肾毒性药物相关的急性肾损伤。
J Pediatr. 2019 Dec;215:223-228.e6. doi: 10.1016/j.jpeds.2019.08.046.
9
Identifying High-Risk Medications Associated with Acute Kidney Injury in Critically Ill Patients: A Pharmacoepidemiologic Evaluation.识别危重症患者中与急性肾损伤相关的高风险药物：一项药物流行病学评估。
Paediatr Drugs. 2017 Feb;19(1):59-67. doi: 10.1007/s40272-016-0205-1.
10
Reducing acute kidney injury in pediatric oncology patients: An improvement project targeting nephrotoxic medications.降低儿科肿瘤患者急性肾损伤发生率：以肾毒性药物为目标的改进项目。
Pediatr Blood Cancer. 2020 Aug;67(8):e28396. doi: 10.1002/pbc.28396. Epub 2020 Jun 3.
本文引用的文献
1
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury.支链氨基酸分解代谢的激活可预防肾毒性急性肾损伤。
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F152-F163. doi: 10.1152/ajprenal.00260.2024. Epub 2024 Dec 9.
2
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease.慢性肾脏病中炎症与纤维化交叉点上的代谢
Nat Rev Nephrol. 2025 Jan;21(1):39-56. doi: 10.1038/s41581-024-00889-z. Epub 2024 Sep 17.
3
Amino acid metabolism in kidney health and disease.肾脏健康与疾病中的氨基酸代谢。
Nat Rev Nephrol. 2024 Dec;20(12):771-788. doi: 10.1038/s41581-024-00872-8. Epub 2024 Aug 28.
4
Deceased donor kidney function and branched chain amino acid metabolism during ex vivo normothermic perfusion.离体常温灌流过程中供体肾脏功能和支链氨基酸代谢。
Kidney Int. 2024 Oct;106(4):712-722. doi: 10.1016/j.kint.2024.06.026. Epub 2024 Jul 27.
5
The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.BCDK 抑制剂 BT2 是一种化学解偶联剂，可降低线粒体 ROS 产生和从头脂肪生成。
J Biol Chem. 2024 Mar;300(3):105702. doi: 10.1016/j.jbc.2024.105702. Epub 2024 Jan 30.
6
MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease.微小 RNA 介导的支链氨基酸分解代谢减弱促进慢性肾脏病中的铁死亡。
Nat Commun. 2023 Nov 28;14(1):7814. doi: 10.1038/s41467-023-43529-z.
7
Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.Krüppel 样因子 6 介导的支链氨基酸分解代谢缺失导致小鼠和人类的肾脏损伤。
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). doi: 10.1073/pnas.2024414118.
8
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.支链氨基酸的不良代谢作用是由异亮氨酸和缬氨酸介导的。
Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21.
9
NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury.基于 NMR 的血清和尿液代谢组学图谱揭示了实验性脓毒症相关急性肾损伤中线粒体途径的抑制。
Am J Physiol Renal Physiol. 2021 May 1;320(5):F984-F1000. doi: 10.1152/ajprenal.00582.2020. Epub 2021 Apr 12.
10
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection.肾脏生理学与急性肾损伤易感性：对肾脏保护的启示。
Nat Rev Nephrol. 2021 May;17(5):335-349. doi: 10.1038/s41581-021-00394-7. Epub 2021 Feb 5.
Zotero 插件