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Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia.

作者信息

Updike S J

出版信息

Bibl Haematol. 1985(51):65-74.

PMID:4004765
Abstract

Autologous red blood cells were loaded with L-asparaginase and injected intravenously into monkeys. A single dose of 1850 IU/Kg suppressed plasma asparagine for 19 days compared to 10 days for the same dose injected free in solution. Rabbit antisera to asparaginase was used to passively immunize guinea-pigs. These animals were then challenged with RBC-entrapped asparaginase versus asparaginase free in solution. RBC entrapment allowed a ten fold greater dose of asparaginase before anaphylaxis became a problem. RBC entrapment prolongs the duration of action of asparaginase and offers protection against anaphylaxis. Clinical trial in patients with acute lymphoblastic leukemia is recommended.

摘要

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