Cherkaoui Abdessalam, Francois Patrice, Gaia Nadia, Renzi Gesuele, Fischer Adrien, Schrenzel Jacques
Bacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205, Geneva, Switzerland.
Genomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, Geneva, Switzerland.
Eur J Clin Microbiol Infect Dis. 2025 May;44(5):1273-1277. doi: 10.1007/s10096-025-05093-w. Epub 2025 Mar 6.
The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.
在一些亚洲国家观察到流感嗜血杆菌中出现了多重耐药（MDR）甚至广泛耐药（XDR）菌株。在此，我们报告了在瑞士日内瓦分离出的首例XDR流感嗜血杆菌。该菌株是从一名63岁男性患者的高质量痰液样本中分离出来的。当时未诊断出呼吸道感染。该菌株不可分型且对泛β-内酰胺耐药。根据全基因组测序分析，它属于序列型159和ST-107克隆复合体。根据在PBP3转肽酶结构域中鉴定出的氨基酸取代，它被归类为III+组。
