Aho K, Palosuo T, Raunio V, Puska P, Aromaa A, Salonen J T
Arthritis Rheum. 1985 May;28(5):485-9. doi: 10.1002/art.1780280503.
Stored serum specimens collected in connection with a community-oriented epidemiologic study were available from 30 subjects who later developed seropositive rheumatoid arthritis. In 9 of these pre-rheumatoid specimens, the Rose-Waaler test result was positive, and in 16, the latex fixation test was positive. Two-thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was less than 4 years, and one-third were positive when the interval was greater than or equal to 4 years. The occurrence of rheumatoid factor preceded the onset of clinical disease more often in males than in females.
在一项以社区为导向的流行病学研究中收集的血清标本可供30名后来出现血清阳性类风湿性关节炎的受试者使用。在这些类风湿病前期标本中，9份Rose-Waaler试验结果呈阳性，16份乳胶凝集试验呈阳性。当采血标本与疾病发作之间的间隔小于4年时，三分之二的样本呈阳性；当间隔大于或等于4年时，三分之一的样本呈阳性。类风湿因子的出现先于临床疾病发作的情况在男性中比在女性中更常见。
