Mitsuyuki Satoshi, Okazaki Sayaka, Mukai Satoru, Matsuura Ai, Yasuhara Yumiko, Tanaka Aya, Oshima Koichi, Hatanaka Kazuo
Department of Hematology Sakai City Medical Center Sakai Japan.
Department of Pathology and Laboratory Sakai City Medical Center Sakai Japan.
EJHaem. 2025 Mar 6;6(2):e1082. doi: 10.1002/jha2.1082. eCollection 2025 Apr.
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) has a high relapse rate. However, it typically remains confined to the skin and has a favorable long-term prognosis. We describe a case of PC-ALCL that experienced a relapse in the central nervous system (CNS). The patient presented with somatosensory abnormalities in the extremities after local treatment of skin lesions and was diagnosed with CNS relapse of PC-ALCL. Methotrexate, procarbazine, and vincristine therapy, and alternating brentuximab vedotin, followed by autologous hematopoietic stem cell transplantation (ASCT) cured the CNS lesions, whereas the skin lesions relapsed early. PC-ALCL could relapse in the CNS; systemic chemotherapy and ASCT may be effective.
原发性皮肤间变性大细胞淋巴瘤（PC-ALCL）复发率高。然而，它通常局限于皮肤，长期预后良好。我们描述了1例PC-ALCL中枢神经系统（CNS）复发的病例。该患者在皮肤病变局部治疗后出现肢体感觉异常，被诊断为PC-ALCL的CNS复发。甲氨蝶呤、丙卡巴肼和长春新碱治疗，交替使用本妥昔单抗，随后进行自体造血干细胞移植（ASCT）治愈了CNS病变，而皮肤病变早期复发。PC-ALCL可在CNS复发；全身化疗和ASCT可能有效。
