Liu Zhenyu, Xu Hongbo, Chen Zhihua
Department of Traditional Chinese Medicine, Yanbian University of Medical College, Jilin Province, 133001, China.
Department of Medical Yanbian of Traditional Chinese Medicine Hospital, Jilin Province, 133000, China.
Clin Exp Med. 2025 Mar 7;25(1):76. doi: 10.1007/s10238-025-01567-5.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic inflammatory responses in the joints, synovial hyperplasia, persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs), and cartilage erosion, leading to joint swelling and destruction. The underlying mechanisms of this disease entail a complex interplay of factors, with long noncoding RNAs (lncRNAs) serving as the main contributors. These lncRNAs, which are over 200 bp in length, are involved in regulating inflammatory responses, joint damage, and FLS growth. Studies have shown that lncRNAs have a dual function in the progression of RA, as they can both promote the disease and control inflammatory responses to reduce symptoms. Nevertheless, our current understanding of the dual function of lncRNAs in the development of RA is incomplete, and the exact molecular mechanisms involved in this process remain unclear. This study aims to elucidate the molecular mechanisms by which lncRNAs exert their inhibitory and stimulatory effects, as well as explore the potential of lncRNAs in diagnosing, predicting the prognosis, and targeting therapy for RA.
类风湿关节炎（RA）是一种慢性自身免疫性疾病，其特征为关节的慢性炎症反应、滑膜增生、成纤维样滑膜细胞（FLS）持续异常增殖以及软骨侵蚀，导致关节肿胀和破坏。该疾病的潜在机制涉及多种因素的复杂相互作用，其中长链非编码RNA（lncRNA）是主要因素。这些长度超过200 bp的lncRNA参与调节炎症反应、关节损伤和FLS生长。研究表明，lncRNA在RA进展中具有双重作用，既能促进疾病发展，又能控制炎症反应以减轻症状。然而，我们目前对lncRNA在RA发生发展中的双重作用的理解并不完整，这一过程中涉及的确切分子机制仍不清楚。本研究旨在阐明lncRNA发挥抑制和刺激作用的分子机制，并探索lncRNA在RA诊断、预后预测和靶向治疗方面的潜力。
