Understanding the role of small-molecule therapeutics for snake envenoming.
作者信息
Silva Anjana, Isbister Geoffrey
机构信息
Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, 50008, Sri Lanka.
Clinical Toxicology Research Group, University of Newcastle, Australia.
出版信息
EBioMedicine. 2025 Apr;114:105635. doi: 10.1016/j.ebiom.2025.105635. Epub 2025 Mar 6.
Abstract
摘要
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本文引用的文献
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Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.用于治疗蛇咬伤中毒的二巯丙磺钠口服疗法的开发：一项针对肯尼亚健康成年人的1期开放标签剂量递增安全性试验和药代动力学分析。
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The critical time period for administering antivenom: golden hours and missed opportunities.抗蛇毒血清给药的关键时间窗：黄金时间和错失的机会。
Clin Toxicol (Phila). 2024 May;62(5):277-279. doi: 10.1080/15563650.2024.2352026. Epub 2024 May 28.
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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms.经重新利用的药物及其组合可预防多种细胞毒性蛇毒液引起的致发病性皮肤坏死。
Nat Commun. 2023 Dec 14;14(1):7812. doi: 10.1038/s41467-023-43510-w.
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Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.一种重新利用的金属螯合剂作为血液毒性蛇咬伤早期干预疗法的临床前验证。
Sci Transl Med. 2020 May 6;12(542). doi: 10.1126/scitranslmed.aay8314.
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Current research into snake antivenoms, their mechanisms of action and applications.当前对蛇抗蛇毒血清的研究、作用机制及应用。
Biochem Soc Trans. 2020 Apr 29;48(2):537-546. doi: 10.1042/BST20190739.
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Long-term Effects of Snake Envenoming.蛇伤的长期影响。
Toxins (Basel). 2019 Mar 31;11(4):193. doi: 10.3390/toxins11040193.
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Toxins (Basel). 2017 Sep 18;9(9):290. doi: 10.3390/toxins9090290.
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Adverse reactions to snake antivenom, and their prevention and treatment.蛇抗毒血清的不良反应及其预防和治疗。
Br J Clin Pharmacol. 2016 Mar;81(3):446-52. doi: 10.1111/bcp.12739. Epub 2015 Sep 16.
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PLoS Med. 2008 Nov 4;5(11):e218. doi: 10.1371/journal.pmed.0050218.
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