Wang Lina, Wang Min, Liu Xiaojun, Tian Jiaqi, Zhang Ling, Li Yuanyuan
Department of Nursing, Weifang People's Hospital, Weifang, China.
Intensive Care Unit, East Branch, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
J Affect Disord. 2025 Jun 15;379:502-509. doi: 10.1016/j.jad.2025.03.023. Epub 2025 Mar 5.
Depression is associated with inflammation, and the uric acid to HDL-C cholesterol ratio (UHR) has emerged as a potential marker of increased inflammation; however, the association between UHR and depression is unclear. Therefore, we aimed to explore this association in a sample from the general US population.
We conducted a cross-sectional study of 11,444 participants ≥20 years of age from the 2009-2014 NHANES database. We conducted weighted multivariate logistic regression analyses and restricted cubic spline function (RCS) models exploring the association between UHR and risk of depression, as well as subgroup analyses and tests of interaction.
UHR was positively associated with depression, especially in participants who drank alcohol (interaction P < 0.05).The prevalence of depression increased by 4 % for each 1-unit increase in UHR (OR = 1.04, 95 % CI = 1.02, 1.07, P = 0.003). After dividing the UHR into quartiles compared with the lowest reference group for UHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustment (OR = 1.36, 95 % CI = 1.03, 1.80, P = 0.033).There was a linear dose-response relationship between the UHR and the risk of depression (P for nonlinear = 0.744).
As this was a cross-sectional study, we could not determine a causal relationship between UHR and depression.
The UHR is positively associated with an increased prevalence of depression among adults in the U.S.
抑郁症与炎症相关，尿酸与高密度脂蛋白胆固醇比值（UHR）已成为炎症增加的一个潜在标志物；然而，UHR与抑郁症之间的关联尚不清楚。因此，我们旨在对来自美国普通人群的样本进行此项关联研究。
我们对2009 - 2014年美国国家健康与营养检查调查（NHANES）数据库中11444名年龄≥20岁的参与者进行了横断面研究。我们进行了加权多变量逻辑回归分析和限制立方样条函数（RCS）模型，以探讨UHR与抑郁症风险之间的关联，以及亚组分析和交互作用检验。
UHR与抑郁症呈正相关，尤其是在饮酒者中（交互作用P < 0.05）。UHR每增加1个单位，抑郁症患病率增加4%（比值比[OR]=1.04，95%置信区间[CI]=1.02, 1.07，P = 0.003）。将UHR分为四分位数后，与UHR最低参考组相比，第四四分位数的参与者在完全调整后抑郁症风险显著增加（OR = 1.36，95% CI = 1.03, 1.80，P = 0.033）。UHR与抑郁症风险之间存在线性剂量反应关系（非线性P = 0.744）。
由于这是一项横断面研究，我们无法确定UHR与抑郁症之间的因果关系。
在美国成年人中，UHR与抑郁症患病率增加呈正相关。
