猪离体肾动脉对跨壁电刺激和药物的反应。
Responses of the pig isolated renal artery to transmural electrical stimulation and drugs.
作者信息
Ferguson D R, Johnson B I, Price N
出版信息
Br J Pharmacol. 1985 Apr;84(4):879-82. doi: 10.1111/j.1476-5381.1985.tb17382.x.
Pig isolated renal arteries contract in response to addition of noradrenaline, 5-hydroxytryptamine, histamine, angiotensin II, vasopressin and carbachol, whereas cholecystokinin, adenosine, and inosine produce relaxation. Transmural stimulation of the tissue causes contraction of circular muscle in the arterial wall which produces apparent elongation of the vessel. The effects of transmural stimulation are partially blocked by prazosin and potentiated by propranolol, indicating that noradrenaline acts through both alpha- and beta-adrenoceptors. Guanethidine (10(-5) M) reduces the size of responses to transmural stimulation in the presence of both prazosin (10(-6) M) and propranolol (10(-7) M). Both saralasin (10(-7) M), and desensitization of angiotensin II receptors by prolonged contact with the peptide, produced a reduction in response to transmural stimulation, indicating that angiotensin II may be involved in neurotransmission. This effect was blocked by tetrodotoxin. Transmural stimulation produces relaxation of renal arteries in the presence of maximal doses of saralasin, prazosin, and propranolol, suggesting that a third unidentified substance is also released from autonomic nerves.
猪的离体肾动脉在加入去甲肾上腺素、5-羟色胺、组胺、血管紧张素II、血管加压素和卡巴胆碱后会收缩，而胆囊收缩素、腺苷和肌苷则会使其舒张。对该组织进行跨壁刺激会导致动脉壁中环行肌收缩，从而使血管明显伸长。跨壁刺激的作用部分被哌唑嗪阻断，而被普萘洛尔增强，这表明去甲肾上腺素通过α和β肾上腺素能受体起作用。胍乙啶（10⁻⁵ M）在存在哌唑嗪（10⁻⁶ M）和普萘洛尔（10⁻⁷ M）的情况下会减小对跨壁刺激的反应大小。沙拉新（10⁻⁷ M）以及通过与该肽长时间接触使血管紧张素II受体脱敏，都会导致对跨壁刺激的反应减弱，这表明血管紧张素II可能参与神经传递。这种作用被河豚毒素阻断。在存在最大剂量的沙拉新、哌唑嗪和普萘洛尔时，跨壁刺激会使肾动脉舒张，这表明自主神经还会释放第三种未确定的物质。
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