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生物适配器植入30个月后冠状动脉的生理性支架重塑

Physiological Scaffold Remodeling in the Coronary Artery After 30 Months of Bioadaptor Implantation.

作者信息

Kawakami Shiori, Takahashi Akihiko, Taniguchi Norimasa, Yamada Takeshi, Hata Tetsuya, Nakajima Shunsuke, Saito Shigeru

机构信息

Department of Cardiology, Sakurakai Takahashi Hospital, Kobe, Japan.

Department of Cardiology, Sakurakai Takahashi Hospital, Kobe, Japan; Graduate School, Kobe Women's University, Kobe, Japan.

出版信息

JACC Case Rep. 2025 Mar 5;30(5):103089. doi: 10.1016/j.jaccas.2024.103089.

DOI:10.1016/j.jaccas.2024.103089
PMID:40054935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11911838/
Abstract

The DynamX Bioadaptor (Elixir Medical Corporation) is a novel coronary artery scaffold consisting of 3 helical strands connected by a bioabsorbable polymer. After 6 months, the polymer dissolves, restoring the physiological motion of the coronary artery as the interconnected (caged) structure of the scaffold disengages. Here we report the cases of 2 patients treated with the Bioadaptor who underwent intravascular imaging at the time of the index procedure and during follow-up periods of 30 and 36 months, respectively. The cross-sectional images of the scaffold were analyzed and compared with those obtained during the index procedure. At follow-up, the mean cross-sectional area of the scaffold was increased significantly in both cases, regardless of the degree of intimal hyperplasia. Such unique properties of the Bioadaptor make it a promising alternative to contemporary drug-eluting stents.

摘要

DynamX生物适配器(Elixir医疗公司)是一种新型冠状动脉支架,由3条螺旋线组成,通过生物可吸收聚合物连接。6个月后,聚合物溶解,随着支架相互连接(笼状)结构分离,冠状动脉的生理运动得以恢复。在此,我们报告2例接受生物适配器治疗的患者病例,这2例患者在初次手术时以及分别在30个月和36个月的随访期内接受了血管内成像检查。对支架的横截面图像进行了分析,并与初次手术时获得的图像进行了比较。随访时,无论内膜增生程度如何,两例患者支架的平均横截面积均显著增加。生物适配器的这种独特特性使其成为当代药物洗脱支架的一个有前景的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/13eae4a5f069/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/4797a42db880/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/de67f8ecf06d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/13eae4a5f069/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/4797a42db880/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/de67f8ecf06d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/11911838/13eae4a5f069/gr2.jpg

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本文引用的文献

1
Final 36-Month Outcomes from the Multicenter DynamX Study Evaluating a Novel Thin-Strut Novolimus-Eluting Coronary Bioadaptor System and Supporting Preclinical Data.评估新型薄支撑诺伐他汀洗脱冠状动脉生物适配系统的多中心DynamX研究的36个月最终结果及临床前数据支持
Rev Cardiovasc Med. 2023 Aug 1;24(8):221. doi: 10.31083/j.rcm2408221. eCollection 2023 Aug.
2
First randomised controlled trial comparing the sirolimus-eluting bioadaptor with the zotarolimus-eluting drug-eluting stent in patients with coronary artery lesions: 12-month clinical and imaging data from the multi-centre, international, BIODAPTOR-RCT.第一项比较西罗莫司洗脱生物适配器与佐他莫司洗脱药物洗脱支架治疗冠状动脉病变患者的随机对照试验:来自多中心、国际BIODAPTOR-RCT的12个月临床和影像学数据。
EClinicalMedicine. 2023 Oct 24;65:102304. doi: 10.1016/j.eclinm.2023.102304. eCollection 2023 Nov.
3
Adaptive Coronary Artery Rotational Motion Through Uncaging of a Drug-Eluting Bioadaptor Aiming to Reduce Stress on the Coronary Artery.通过释放载药生物适应器实现冠状动脉的适应性旋转运动,旨在减轻冠状动脉的压力。
Cardiovasc Revasc Med. 2022 Jun;39:52-57. doi: 10.1016/j.carrev.2021.09.009. Epub 2021 Oct 2.
4
Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials.《临床心脏病学进展 2020:重点临床试验总结》。
Adv Ther. 2021 May;38(5):2170-2200. doi: 10.1007/s12325-021-01711-z. Epub 2021 Apr 12.
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Twelve-month clinical and imaging outcomes of the uncaging coronary DynamX bioadaptor system.冠状动脉 DynamX 生物适应器系统的 12 个月临床和影像学结果。
EuroIntervention. 2020 Dec 18;16(12):e974-e981. doi: 10.4244/EIJ-D-20-00763.
6
Stent-Related Adverse Events >1 Year After Percutaneous Coronary Intervention.支架相关不良事件 >1 年经皮冠状动脉介入治疗后。
J Am Coll Cardiol. 2020 Feb 18;75(6):590-604. doi: 10.1016/j.jacc.2019.11.058.
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J Am Coll Cardiol. 2015 Jun 16;65(23):2496-507. doi: 10.1016/j.jacc.2015.04.017.
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