Mupfuti Rumbidzai, Kabudula Chodziwadziwa W, Francis Joel Msafiri
Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Sci Rep. 2025 Mar 7;15(1):7951. doi: 10.1038/s41598-025-91704-7.
Chronic diseases are significant problems in South Africa. Chronic diseases' treatment outcomes are critical to the reduction of morbidity and mortality. There is limited data in South Africa on alcohol use and treatment outcomes of chronic diseases in older people. Understanding the association between alcohol use and chronic diseases treatment outcomes would inform potential interventions to address the duo. We analysed data from wave 1 of the Health and Ageing in Africa-a longitudinal Study in an INDEPTH community (HAALSI) study. We performed descriptive analysis to determine the prevalence of optimal chronic diseases' treatment outcomes (suppressed HIV viral load, normal blood pressure and normal blood sugar- euglycemia) and applied modified Poisson regression to determine the association between alcohol use and chronic diseases' treatment outcomes. The prevalence of optimal treatment outcomes was 87.4% suppressed viral load for those living with HIV, 42.7% normal blood pressure for hypertensives, 53.6% with euglycemia among diabetics and 52.4% with normal outcome parameters among those with multimorbidity. Alcohol use did not negatively impact the optimal treatment outcomes for HIV (aRR = 1.00, 95%CI 0.93-1.09), hypertension (aRR = 0.88, 95%CI 0.68-1.14), diabetes mellitus (aRR = 0.73, 95%CI 0.44-1.22), and multimorbidity (aRR = 1.00, 95%CI 0.93-1.09). Alcohol use was not significantly associated with treatment outcomes possibly due to underreporting of alcohol use. There is need to incorporate objective alcohol measurements and alcohol interventions in chronic diseases care settings. Furthermore, there is urgent need to strengthen the management of hypertension and diabetes, by adopting the strategies deployed for HIV management.
慢性病是南非的重大问题。慢性病的治疗结果对于降低发病率和死亡率至关重要。南非关于老年人饮酒与慢性病治疗结果的数据有限。了解饮酒与慢性病治疗结果之间的关联将为应对这一双重问题的潜在干预措施提供信息。我们分析了非洲健康与老龄化纵向研究——深入社区研究(HAALSI)第一波的数据。我们进行了描述性分析,以确定最佳慢性病治疗结果(HIV病毒载量被抑制、血压正常和血糖正常——血糖正常)的患病率,并应用修正泊松回归来确定饮酒与慢性病治疗结果之间的关联。最佳治疗结果的患病率为:HIV感染者中病毒载量被抑制的比例为87.4%,高血压患者中血压正常的比例为42.7%,糖尿病患者中血糖正常的比例为53.6%,患有多种疾病的患者中结果参数正常的比例为52.4%。饮酒对HIV(调整后风险比[aRR]=1.00,95%置信区间[CI]0.93 - 1.09)、高血压(aRR = 0.88,95%CI 0.68 - 1.14)、糖尿病(aRR = 0.73,95%CI 0.44 - 1.22)和多种疾病(aRR = 1.00,95%CI 0.93 - 1.09)的最佳治疗结果没有负面影响。饮酒与治疗结果可能没有显著关联,这可能是由于饮酒情况报告不足。在慢性病护理环境中需要纳入客观的酒精测量和酒精干预措施。此外,迫切需要通过采用用于HIV管理的策略来加强高血压和糖尿病的管理。