Durstenfeld Matthew S, Hill C Larry, Clare Robert M, Chiswell Karen, Sanders Gretchen, Gray Shamea, Vicini Joseph, Marsolo Keith, Okeke Nwora Lance, Meissner Eric G, Thomas Kevin L, Morse Caryn G, Bloomfield Gerald S, Pettit April C, Longenecker Chris T
Division of Cardiology at Zuckerberg San Francisco General University of California San Francisco San Francisco CA USA.
Duke Clinical Research Institute Durham NC USA.
J Am Heart Assoc. 2025 Mar 18;14(6):e038462. doi: 10.1161/JAHA.124.038462. Epub 2025 Mar 7.
People with HIV (PWH) have elevated cardiovascular risk. Underrepresented racial and ethnic groups in the southern United States are disproportionately affected, yet whether cardiology care for this at-risk group improves blood pressure and lipid control or prevents cardiovascular events is unknown.
We evaluated a cohort of PWH from underrepresented racial and ethnic groups who received HIV-related care at 4 centers in the southern United States during 2015 to 2018 with follow-up through 2020. Primary outcomes were blood pressure control (<140/90 mm Hg) and lipid control (low-density lipoprotein cholesterol ≤100 mg/dL) over 2 years and time to first major adverse cardiovascular event. Statistical analyses were adjusted for cohort/site and patient sociodemographic factors, HIV measures, and comorbidities. Among 3972 included PWH (median age, 47 years; 32.6% women) without diagnosed cardiovascular disease, 276 (6.9%) had a cardiology clinic visit. Cardiology visits were not associated with subsequent blood pressure control (adjusted odds ratio, 0.78 [95% CI, 0.49-1.24]; =0.29) or lipid control (adjusted odds ratio, 2.25 [95% CI, 0.72-7.01]; =0.16). Over 5-year follow-up, patients who had a cardiology visit had a higher risk of a major adverse cardiovascular event, death, and falsification end points, even after adjusting for measured risk factors.
Among PWH from underrepresented racial and ethnic groups at elevated risk for cardiovascular disease, a cardiology clinic visit was not associated with risk factor improvement or reduced risk of a major adverse cardiovascular event. Our study suggests that seeing a cardiologist is not sufficient to promote cardiovascular health or prevent cardiovascular events among PWH, but with low confidence given the higher risk among those who had a cardiology visit.
感染艾滋病毒的人(PWH)心血管疾病风险升高。美国南部代表性不足的种族和族裔群体受到的影响尤为严重,但针对这一高危群体的心脏病护理能否改善血压和血脂控制或预防心血管事件尚不清楚。
我们评估了2015年至2018年期间在美国南部4个中心接受艾滋病毒相关护理并随访至2020年的代表性不足的种族和族裔群体的PWH队列。主要结局是2年内的血压控制(<140/90 mmHg)和血脂控制(低密度脂蛋白胆固醇≤100 mg/dL)以及首次发生重大不良心血管事件的时间。统计分析针对队列/地点和患者社会人口学因素、艾滋病毒指标及合并症进行了调整。在3972名未被诊断患有心血管疾病的纳入研究的PWH中(年龄中位数为47岁;32.6%为女性),276人(6.9%)曾到心脏病诊所就诊。心脏病就诊与随后的血压控制(调整后的优势比为0.78 [95%可信区间,0.49 - 1.24];P = 0.29)或血脂控制(调整后的优势比为2.25 [95%可信区间,0.72 - 7.01];P = 0.16)无关。在5年的随访中,即使在对测量的风险因素进行调整后,曾到心脏病诊所就诊的患者发生重大不良心血管事件、死亡和伪造终点的风险更高。
在心血管疾病风险升高的代表性不足的种族和族裔群体的PWH中,到心脏病诊所就诊与风险因素改善或重大不良心血管事件风险降低无关。我们的研究表明,看心脏病专家不足以促进PWH的心血管健康或预防心血管事件,但鉴于就诊者风险较高,此结论可信度较低。