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Secondary resistance to sonidegib is rare in locally advanced basal cell carcinoma.

作者信息

Muñoz Couselo Eva, Berking Carola, Baurain Jean François, Martelli Serena, Arntz Ramon, Savoia Paola

机构信息

Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Vall d'Hebron Institute of Oncology, Barcelona, Spain.

出版信息

J Eur Acad Dermatol Venereol. 2025 Sep;39(9):e788-e790. doi: 10.1111/jdv.20629. Epub 2025 Mar 8.

DOI:10.1111/jdv.20629
PMID:40055950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12376237/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73d/12376237/58c90dfea8a7/JDV-39-e788-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73d/12376237/f779c7de3c3d/JDV-39-e788-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73d/12376237/58c90dfea8a7/JDV-39-e788-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73d/12376237/f779c7de3c3d/JDV-39-e788-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73d/12376237/58c90dfea8a7/JDV-39-e788-g002.jpg

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本文引用的文献

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Phase 2 open-label, multicenter, single-arm study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Extended follow-up.西米普利单抗用于刺猬抑制剂治疗后局部晚期基底细胞癌患者的2期开放标签、多中心、单臂研究：延长随访
J Am Acad Dermatol. 2024 Feb;90(2):414-418. doi: 10.1016/j.jaad.2023.08.111. Epub 2023 Oct 14.
2
Clinical Characteristics of an Italian Patient Population with Advanced BCC and Real-Life Evaluation of Hedgehog Pathway Inhibitor Safety and Effectiveness.晚期基底细胞癌意大利患者人群的临床特征及 Hedgehog 通路抑制剂安全性和有效性的真实世界评估。
Dermatology. 2023;239(6):868-876. doi: 10.1159/000531280. Epub 2023 Jun 13.
3
Sonidegib as a Locally Advanced Basal Cell Carcinoma Therapy in Real-life Clinical Setting: A National Multicentre Study.
在现实临床环境中，索尼德吉作为局部晚期基底细胞癌的治疗方法：一项全国多中心研究。
Actas Dermosifiliogr. 2023 Jul-Aug;114(7):565-571. doi: 10.1016/j.ad.2023.04.022. Epub 2023 Apr 23.
4
Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance.刺猬通路抑制剂作为靶向癌症治疗药物和克服耐药性的策略。
Int J Mol Sci. 2022 Feb 3;23(3):1733. doi: 10.3390/ijms23031733.
5
Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma.局部晚期基底细胞癌中维莫德吉内在耐药的频率和基因组方面。
Clin Cancer Res. 2022 Apr 1;28(7):1422-1432. doi: 10.1158/1078-0432.CCR-21-3764.
6
Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase II randomized, double-blind BOLT study.索立德吉治疗晚期基底细胞癌的长期疗效和安全性：II 期随机、双盲 BOLT 研究的 42 个月分析。
Br J Dermatol. 2020 Jun;182(6):1369-1378. doi: 10.1111/bjd.18552. Epub 2019 Dec 8.
7
Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin.小分子抑制剂在治疗皮肤基底细胞癌中的 Hedgehog 通路作用。
Am J Clin Dermatol. 2018 Apr;19(2):195-207. doi: 10.1007/s40257-017-0319-4.
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Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.索立德吉治疗局部晚期和转移性基底细胞癌患者的长期疗效和安全性：随机 2 期 BOLT 研究的 30 个月分析。
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):372-381. doi: 10.1111/jdv.14542. Epub 2017 Nov 6.
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J Am Acad Dermatol. 2015 Jun;72(6):1021-6.e8. doi: 10.1016/j.jaad.2015.03.021.