Arbilla S, Nowak J Z, Langer S Z
Brain Res. 1985 Jun 24;337(1):11-7. doi: 10.1016/0006-8993(85)91605-1.
When nomifensine is employed to inhibit neuronal uptake, exposure to dopamine (DA) (0.1-0.3 microM) or apomorphine (0.01-0.1 microM) inhibited, in a concentration-dependent manner, the electrically evoked release of [3H]dopamine from slices of the rabbit caudate nucleus. Apomorphine inhibited transmitter release independently of the time of exposure to the drug (6-32 min). On the other hand, the inhibitory effect of exogenous dopamine occurred only if a short period (4-12 min) of exposure was employed. In studies on the electrically evoked release of [3H]acetylcholine in slices of the rabbit caudate nucleus there was no evidence for desensitization to apomorphine or exogenous dopamine at the level of the dopamine receptors that inhibit [3H]acetylcholine release. These results indicate that the dopamine autoreceptors modulating [3H]dopamine release in the caudate nucleus become subsensitive after a few minutes of exposure to exogenous dopamine. This effect does not occur at the level of the dopamine receptors which inhibit the release of [3H]acetylcholine.
当使用诺米芬辛抑制神经元摄取时，暴露于多巴胺（DA）（0.1 - 0.3微摩尔）或阿扑吗啡（0.01 - 0.1微摩尔）会以浓度依赖性方式抑制兔尾状核切片中电诱发的[3H]多巴胺释放。阿扑吗啡抑制递质释放，与药物暴露时间（6 - 32分钟）无关。另一方面，外源性多巴胺的抑制作用仅在短时间（4 - 12分钟）暴露时才会出现。在对兔尾状核切片中电诱发的[3H]乙酰胆碱释放的研究中，没有证据表明在抑制[3H]乙酰胆碱释放的多巴胺受体水平上对阿扑吗啡或外源性多巴胺脱敏。这些结果表明，在暴露于外源性多巴胺几分钟后，调节尾状核中[3H]多巴胺释放的多巴胺自身受体会变得不敏感。这种效应在抑制[3H]乙酰胆碱释放的多巴胺受体水平上不会发生。
