Sevimli Neslihan, İren Ece, Taydaş Güneş, Azarbaz Muhammed Kaan
Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, Ataşehir, Istanbul, Turkey.
Jpn J Ophthalmol. 2025 May;69(3):351-359. doi: 10.1007/s10384-025-01182-7. Epub 2025 Mar 8.
To use anterior segment optical coherence tomography (AS-OCT) to investigate differences in punctal dimensions, tear meniscus height (TMH), and cornea among epiphora patients and healthy individuals; to assess its utility in screening and diagnosing epiphora; and to examine its effects on the cornea.
Prospective, cross-sectional METHODS: A total of 43 patients (31 women) with epiphora (Munk score >2) and 58 healthy individuals (38 women) without ocular symptoms were enrolled in this study. AS-OCT (Maestro, Topcon) was used to measure TMH, outer punctal diameter (OPD), punctal depth (PD), and corneal epithelial thickness (CET). Corneal topography (Pentacam, Oculus) was used to assess corneal topographic parameters and corneal volume (CV). Correlations among OPD, TMH, and corneal parameters were analyzed.
No significant differences were found in age and sex among the groups (P = .909 and P = .482, respectively). Patients with epiphora exhibited significantly narrower OPD (229.6 ± 150.1 μm) and higher TMH (592.5 ± 315.3 μm) (both P <.001). CV was notably lower in the epiphora group (P = .015). The lower cutoff of OPD for epiphora was found to be 200 μm, and the lower cutoff of TMH for epiphora, 445 μm. Positive correlations were observed between OPD and CV (P = .001).
Patients with epiphora demonstrated narrower OPD, higher TMH, and lower CV than those of healthy individuals. These findings highlight the utility of AS-OCT in assessing epiphora and its effects on corneal health.
运用眼前节光学相干断层扫描(AS - OCT)研究溢泪症患者与健康个体之间泪点尺寸、泪液半月皱襞高度(TMH)及角膜的差异;评估其在溢泪症筛查和诊断中的效用;并检查其对角膜的影响。
前瞻性横断面研究
本研究共纳入43例溢泪症患者(31例女性)(蒙克评分>2)和58例无眼部症状的健康个体(38例女性)。使用AS - OCT(拓普康Maestro)测量TMH、泪点外径(OPD)、泪点深度(PD)和角膜上皮厚度(CET)。使用角膜地形图仪(德国OCULUS公司的Pentacam)评估角膜地形参数和角膜体积(CV)。分析OPD、TMH和角膜参数之间的相关性。
各组间年龄和性别无显著差异(分别为P = 0.909和P = 0.482)。溢泪症患者的OPD显著更窄(229.6 ± 150.1μm),TMH更高(592.5 ± 315.3μm)(均P <0.001)。溢泪症组的CV明显更低(P = 0.015)。发现溢泪症的OPD下限为200μm,TMH下限为445μm。观察到OPD与CV之间存在正相关(P = 0.001)。
与健康个体相比,溢泪症患者的OPD更窄、TMH更高且CV更低。这些发现凸显了AS - OCT在评估溢泪症及其对角膜健康影响方面的效用。