蛛网膜下腔注射布比卡因会降低犬脊髓血流量。

Subarachnoid bupivacaine decreases spinal cord blood flow in dogs.

作者信息

Kozody R, Ong B, Palahniuk R J, Wade J G, Cumming M O, Pucci W R

出版信息

Can Anaesth Soc J. 1985 May;32(3 Pt 1):216-22. doi: 10.1007/BF03015129.

Abstract

Eighteen mongrel dogs were randomized into two equal groups. Cervical, thoracic and lumbosacral spinal cord and spinal dural blood flows were measured using the radioactive microsphere technique. Blood flow determinations were made prior to, and 20 and 40 minutes following lumbar subarachnoid injection of: (1) 0.4 per cent bupivacaine (20 mg), or (2) 0.4 per cent bupivacaine (20 mg) with 1/25,000 epinephrine (200 micrograms). In dogs given subarachnoid bupivacaine or bupivacaine with epinephrine, the maximum decrease in mean arterial blood pressure (33 per cent) occurred at 40 minutes post-injection. Cardiac index decreased in dogs given subarachnoid bupivacaine (197 +/- 11 ml X kg-1 X min-1 control vs. 141 +/- 19 ml X kg-1 X min-1 at 40 minutes), while it increased in dogs given bupivacaine with epinephrine (201 +/- 11 ml X kg-1 X min-1 - control vs. 252 +/- 15 ml X kg-1 X min-1 at 40 minutes). Dogs receiving subarachnoid bupivacaine demonstrated a significant decrease in spinal cord blood flow to all regions. Dogs receiving subarachnoid bupivacaine with epinephrine demonstrated a significant decrease in thoracic and lumbosacral spinal cord blood flow; however, cervical cord blood flow remained unchanged. Thoracic and lumbosacral dural blood flows were significantly decreased in both groups following subarachnoid injection. Subarachnoid bupivacaine 0.4 per cent (20 mg) and 0.4 per cent with epinephrine 1/25,000 (200 micrograms) decrease spinal cord and spinal dural blood flow in dogs.

摘要

18只杂种狗被随机分为两组。采用放射性微球技术测量颈段、胸段和腰骶段脊髓及硬脊膜血流。在腰蛛网膜下腔注射以下药物之前、注射后20分钟和40分钟进行血流测定：（1）0.4%布比卡因（20毫克），或（2）0.4%布比卡因（20毫克）加1/25,000肾上腺素（200微克）。给予蛛网膜下腔布比卡因或布比卡因加肾上腺素的狗，平均动脉血压最大降幅（33%）出现在注射后40分钟。给予蛛网膜下腔布比卡因的狗心脏指数降低（对照时为197±11毫升·千克⁻¹·分钟⁻¹，40分钟时为141±19毫升·千克⁻¹·分钟⁻¹），而给予布比卡因加肾上腺素的狗心脏指数升高（对照时为201±11毫升·千克⁻¹·分钟⁻¹，40分钟时为252±15毫升·千克⁻¹·分钟⁻¹）。接受蛛网膜下腔布比卡因的狗所有区域的脊髓血流均显著减少。接受蛛网膜下腔布比卡因加肾上腺素的狗胸段和腰骶段脊髓血流显著减少；然而，颈段脊髓血流保持不变。两组在蛛网膜下腔注射后胸段和腰骶段硬脊膜血流均显著减少。0.4%（20毫克）蛛网膜下腔布比卡因和0.4%加1/25,000肾上腺素（200微克）可降低狗的脊髓和硬脊膜血流。