Mayer Caleb, Walch Olivia, Dempsey Walter, Hannay Kevin, Clingan Caroline, Bowen Zoe, Rozwadowski Michelle, Reichert Zachery R, Henry N Lynn, Alumkal Joshi J, Tewari Muneesh, Forger Daniel B, Choi Sung Won
Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Arcascope, Arlington, VA 22203, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Cell Rep Med. 2025 Mar 18;6(3):102001. doi: 10.1016/j.xcrm.2025.102001. Epub 2025 Mar 7.
Lighting interventions can mitigate fatigue by promoting circadian rhythmicity. We test whether individualized, wearable-based lighting interventions delivered via a mobile app reduce cancer-related fatigue in a randomized controlled trial with 138 breast cancer, prostate cancer, and hematopoietic stem cell transplant patients. Participants are randomized to tailored lighting intervention or control. The primary endpoint is PROMIS fatigue 4a at trial end, with secondary endpoints including change in daily fatigue, sleep, anxiety, depression, physical function, and overall health. Fatigue T-scores at week 11 do not differ between groups but decrease significantly from week 1 to week 11 (3.07 points, p = 0.001) in the intervention group, with a significant final-week treatment effect (p = 0.014). Daily fatigue, anxiety, sleep disturbance, and physical function improve within intervention. Further studies are needed to see if these results generalize in broader cancer care. The trial is registered at ClinicalTrials.gov (trial registration number: NCT04827446).
光照干预可以通过促进昼夜节律来减轻疲劳。我们在一项随机对照试验中测试了通过移动应用程序提供的个性化、基于可穿戴设备的光照干预是否能减轻138名乳腺癌、前列腺癌和造血干细胞移植患者的癌症相关疲劳。参与者被随机分为量身定制的光照干预组或对照组。主要终点是试验结束时的PROMIS疲劳4a，次要终点包括每日疲劳、睡眠、焦虑、抑郁、身体功能和总体健康状况的变化。第11周时两组的疲劳T评分没有差异，但干预组从第1周到第11周显著下降（3.07分，p = 0.001），且在最后一周有显著的治疗效果（p = 0.014）。干预期间，每日疲劳、焦虑、睡眠障碍和身体功能均有所改善。需要进一步研究以确定这些结果是否能推广到更广泛的癌症护理中。该试验已在ClinicalTrials.gov注册（试验注册号：NCT04827446）。
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