Przyklenk K, Groom A C
Can J Physiol Pharmacol. 1985 Apr;63(4):273-8. doi: 10.1139/y85-049.
In the rat model of chronic myocardial infarction the border or "transition zone," extending 225-525 micron from the margin of the scar, is supplied by significantly fewer capillaries and characterized by an altered capillary-fiber geometry when compared with healthy rat myocardium. Four weeks of daily voluntary running can, under certain conditions, promote capillary growth and a shift in capillary-fiber geometry, such that a normal capillary supply is restored to the transition zone. However, the importance of exercise frequency, intensity, and duration for capillary growth in the transition zone has not been determined. One week after surgical occlusion of the left coronary artery, rats were divided into four groups following different protocols of voluntary exercise (running): A (2 h/day, 6 days/week for 4 weeks), B (2 h/day, 3 days/week for 4 weeks), C (2 h/day, 6 days/week for 2 weeks, followed by 2 weeks sedentary), and D (2 h/day, 6 days/week for 2 weeks). Significant improvements in capillary supply to the transition zone were associated with voluntary exercise, three separate factors being of importance. (i) An intermediate total distance run; rats that ran 5-10 km in the month restored a normal number of capillaries and a normal capillary-fiber geometry in the transition zone, whereas rats that ran either less than 5 or greater than 10 km showed no significant improvements. (ii) A balance between exercise frequency and mean distance run per 2-h exercise period; rats in group B (3 days/week) had to run twice the daily distance of those in group A (6 days/week) to obtain the same improvement in capillary supply.(ABSTRACT TRUNCATED AT 250 WORDS)
在慢性心肌梗死大鼠模型中，从瘢痕边缘延伸225 - 525微米的边界或“过渡区”，与健康大鼠心肌相比，其毛细血管供应显著减少，且毛细血管 - 纤维几何结构改变。在某些条件下，每天进行四周的自愿跑步可促进毛细血管生长以及毛细血管 - 纤维几何结构的转变，从而使过渡区恢复正常的毛细血管供应。然而，运动频率、强度和持续时间对过渡区毛细血管生长的重要性尚未确定。在左冠状动脉手术结扎一周后，大鼠按照不同的自愿运动（跑步）方案分为四组：A组（每天2小时，每周6天，共4周），B组（每天2小时，每周3天，共4周），C组（每天2小时，每周6天，共2周，随后2周 sedentary），D组（每天2小时，每周6天，共2周）。过渡区毛细血管供应的显著改善与自愿运动相关，有三个独立因素很重要。（i）中等的总跑步距离；在一个月内跑5 - 10公里的大鼠，过渡区恢复了正常数量的毛细血管和正常的毛细血管 - 纤维几何结构，而跑步距离小于5公里或大于10公里的大鼠则没有显著改善。（ii）运动频率与每2小时运动时段平均跑步距离之间的平衡；B组（每周3天）的大鼠必须跑A组（每周6天）大鼠每日跑步距离的两倍，才能在毛细血管供应上获得相同的改善。（摘要截断于250字） （注：原文中“sedentary”疑似拼写错误，可能应为“sedentary”，这里按原文翻译）
