BACKGROUND

Pseudomonas aeruginosa and Acinetobacter baumannii are common causes of nosocomial infections. Furthermore, antimicrobial resistance is frequently observed in these pathogens, posing significant challenges to treatment.

OBJECTIVE

This study aimed to determine the prevalence, antimicrobial resistance profiles, and determinants of A baumannii and P aeruginosa isolates among nosocomial infection--suspected patients at Debre Markos Comprehensive Specialized Hospital.

METHODS

An institutional-based cross-sectional study was conducted from March 01, 2021 to May 30, 2021. A consecutive convenient sampling technique was applied to select 200 nosocomial infection--suspected patients. Clinical samples were collected and inoculated on MacConkey agar, blood agar, and Tryptic Soy broth. Testing for antibiotic susceptibility was done on Mueller Hinton agar.

RESULTS

The overall prevalence of A baumannii and P aeruginosa isolates among nosocomial infection--suspected patients was 11.5%. All isolates of P aeruginosa and A baumannii were 100% resistant to cefepime and piperacillin. Prolonged hospitalization and antibiotics use were significant determinants of P aeruginosa and A baumannii--induced nosocomial infection (adjusted odds ratio: 5.691, 95% CI: 1.069-7.296, P<.050 and adjusted odds ratio: 4.199, 95% CI: 0.997-6.675, P<.042, respectively).

CONCLUSIONS

The prevalence of A baumannii and P aeruginosa isolates was high in the study area. Therefore, there should be serious attention to control the spread of drug-resistant nosocomial infections in the study area.