Cole Andrew, Weight Nicholas, Wijeysundera Harindra C, Rashid Muhammad, Yu Dahai, Healey Emma L, Chew Nicholas Ws, Siudak Zbigniew, Khunti Kamlesh, Kontopantelis Evangelos, Mamas Mamas A
Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, United Kingdom.
Schulich Heart Program, Department of Medicine (Cardiology), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Diabetes Res Clin Pract. 2025 Apr;222:112092. doi: 10.1016/j.diabres.2025.112092. Epub 2025 Mar 8.
This study aimed to assess how diabetes influences the quality of care and longer-term outcomes in contemporary STEMI cohorts.
We analysed 283,658 adults hospitalised with STEMI from the United Kingdom Myocardial Ischaemia National Audit Project (MINAP) registry between 2005 and 2019. This was linked with Office of National Statistics data to provide out of hospital mortality outcomes. We compared longer-term outcomes depending on diabetes status and assessed the effect of quality of care using the opportunity-based quality-indicator score (OBQI).
Individuals with diabetes were older (median age 68.7 vs. 65.5), underwent percutaneous coronary intervention less frequently (60 % vs. 63 %) and were less likely to achieve a door-to-balloon time of < 60 min (69 % vs. 75 %) or < 120 min (89 % vs. 92 %). Their adjusted all-cause mortality risk was higher during follow-up, from 30 days (HR: 1.49, CI: 1.44-1.54), to up to 10 years of follow up (HR: 1.54, CI: 1.52-1.57), compared to individuals without diabetes. Excellent inpatient care was associated with lower mortality rates within individuals with diabetes (Diabetes: HR 0.56, CI: 0.50-0.64, No diabetes: HR 0.62, CI: 0.58-0.67).
Individuals with diabetes have a higher risk of long-term mortality after STEMI. They experience delays in angiography and receive lower quality inpatient care.
本研究旨在评估糖尿病如何影响当代ST段抬高型心肌梗死(STEMI)队列中的医疗质量和长期预后。
我们分析了2005年至2019年期间来自英国心肌缺血国家审计项目(MINAP)登记处的283658例因STEMI住院的成年人。这与国家统计局的数据相关联,以提供院外死亡结局。我们根据糖尿病状态比较了长期预后,并使用基于机会的质量指标评分(OBQI)评估了医疗质量的影响。
糖尿病患者年龄更大(中位年龄68.7岁对65.5岁),接受经皮冠状动脉介入治疗的频率更低(60%对63%),且不太可能实现门球时间<60分钟(69%对75%)或<120分钟(89%对92%)。与无糖尿病患者相比,他们在随访期间的调整后全因死亡风险更高,从30天(风险比:1.49,置信区间:1.44-1.54)到长达10年的随访(风险比:1.54,置信区间:1.52-1.57)。在糖尿病患者中,优质的住院治疗与较低的死亡率相关(糖尿病:风险比0.56,置信区间:0.50-0.64,无糖尿病:风险比0.62,置信区间:0.58-0.67)。
糖尿病患者在STEMI后有更高的长期死亡风险。他们在血管造影方面存在延迟,并且接受的住院治疗质量较低。