Song Dongjie, Yang Qianjie, Ge Jiayun, Chen Kuangqi, Tong Jianping, Shen Ye
Department of Ophthalmology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, Zhejiang, China.
Exp Eye Res. 2025 May;254:110324. doi: 10.1016/j.exer.2025.110324. Epub 2025 Mar 7.
As a global public health problem, myopia has attracted more and more attention for its high prevalence and severe visual impairment. Although extensive research on the risk factors for myopia has been conducted, the underlying pathogenesis is still unclear. Color vision, mediated by retinal cone cells, is a fundamental and important component of human visual functions. Indeed, numerous studies implicate color vision-associated environmental and biological factors in myopia pathogenesis, indicating that related interventions may delay myopia progression. Studies have shown that color vision can induce different accommodation responses under near work conditions and exert opposite effects in different light environments to influence myopia advancement. Besides, color vision-related genes and metabolites are proven to be correlated with myopia. This review aims to make detailed elaborations on the role of color vision in myopia and its potential interaction mechanism, hoping to provide new ideas for myopia prevention.
作为一个全球性的公共卫生问题，近视因其高患病率和严重的视力损害而受到越来越多的关注。尽管已经对近视的危险因素进行了广泛研究，但其潜在的发病机制仍不清楚。由视网膜锥细胞介导的色觉是人类视觉功能的一个基本且重要的组成部分。事实上，大量研究表明与色觉相关的环境和生物学因素参与了近视的发病机制，这表明相关干预措施可能会延缓近视进展。研究表明，色觉在近工作条件下可诱导不同的调节反应，并在不同的光照环境中产生相反的作用，从而影响近视进展。此外，已证实与色觉相关的基因和代谢产物与近视有关。本综述旨在详细阐述色觉在近视中的作用及其潜在的相互作用机制，希望为近视预防提供新思路。
