Farahavar Ghazal, Abolmaali Samira Sadat, Biabanikhankahdani Roya, Tamaddon Ali Mohammad
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Nanotechnology Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Crit Rev Oncol Hematol. 2025 May;209:104691. doi: 10.1016/j.critrevonc.2025.104691. Epub 2025 Mar 8.
Malignancies maintain a high rate of mortality worldwide each year, requiring the development of novel therapeutic platforms. Immunotherapy approaches are considered a revolutionary treatment for overcoming malignancies. Photodynamic therapy (PDT) has attracted significant attention in various cancer types. Recent progress in cancer therapies has underscored the potential of combining PDT with immunotherapy. This approach can improve therapeutic outcomes by directly eliminating tumor cells and boosting immune responses for sustained anti-tumor effects in the whole body. This study aims to determine the relative efficacy of combining PDT with immunotherapy compared to PDT alone. Following the PRISMA guidance, an extensive literature review was conducted utilizing Scopus, Web of Science, and PubMed to identify high-quality preclinical studies exploring various aspects of PDT combined with immunotherapy. The adopted PICO framework included studies with rigorous experimental designs and relevant outcomes. The present review reveals the characteristics of tumor models, delivery systems, photosensitizers, and immunotherapy approaches. Key findings indicate that the combined PDT-immunotherapy approach shows promise in treating multiple tumors according to their size, therapeutic biomarkers, and inhibition of distant tumors. Finally, this integrated therapeutic strategy holds significant promise for advancing cancer treatment paradigms by potentiating each treatment efficacy; however, its clinical utility requires careful consideration of the associated challenges.
恶性肿瘤每年在全球范围内保持着较高的死亡率，这就需要开发新的治疗平台。免疫治疗方法被认为是克服恶性肿瘤的一种革命性治疗方法。光动力疗法（PDT）在各种癌症类型中都引起了广泛关注。癌症治疗的最新进展凸显了将PDT与免疫治疗相结合的潜力。这种方法可以通过直接消除肿瘤细胞和增强免疫反应来改善治疗效果，从而在全身产生持续的抗肿瘤作用。本研究旨在确定与单独使用PDT相比，PDT与免疫治疗相结合的相对疗效。按照PRISMA指南，利用Scopus、Web of Science和PubMed进行了广泛的文献综述，以识别探索PDT与免疫治疗相结合各个方面的高质量临床前研究。所采用的PICO框架包括具有严格实验设计和相关结果的研究。本综述揭示了肿瘤模型、给药系统、光敏剂和免疫治疗方法的特点。主要研究结果表明，根据肿瘤大小、治疗生物标志物以及对远处肿瘤的抑制作用，PDT-免疫治疗联合方法在治疗多种肿瘤方面显示出前景。最后，这种综合治疗策略通过增强每种治疗效果，在推进癌症治疗模式方面具有重大前景；然而，其临床实用性需要仔细考虑相关挑战。
