J Tabouni Mahmoud, AbuRamadan Anas, Awouda Samah
Internal Medicine, Hamad Medical Corporation, Doha, QAT.
Cardiology, Hamad Medical Corporation, Doha, QAT.
Cureus. 2025 Feb 3;17(2):e78455. doi: 10.7759/cureus.78455. eCollection 2025 Feb.
(Sidr) is widely used for its medicinal and nutritional properties, with documented pharmacological effects such as antidiabetic, sedative, and antihypertensive activities. However, its consumption, especially in unregulated settings, can pose significant health risks due to potential toxicity and contamination with pesticides. We report the case of a 25-year-old male who presented with severe abdominal pain radiating to the chest, profound bradycardia (heart rate in the 20s), hypotension (systolic blood pressure in the 50s), and autonomic symptoms after ingesting unwashed fruit. Initial investigations revealed Mobitz type I second-degree atrioventricular (AV) block, transient ST depression, and elevated troponin levels, raising suspicion of acute coronary syndrome (ACS). However, comprehensive cardiac evaluations, including CT coronary angiography and cardiac MRI, excluded ischemic and structural cardiac causes. A detailed history revealed the ingestion of unwashed fruit, suggesting toxicity exacerbated by pesticide exposure. The patient responded well to supportive care, including atropine, and was discharged on the fourth day with a complete resolution of symptoms. This case highlights the diagnostic challenge posed by toxic ingestions mimicking ACS. Although it is not clear if induced cardiotoxic effects at higher doses, the pesticide contamination could have also contributed to cardiotoxicity. Clinicians should consider toxicological etiologies in patients presenting with atypical gastrointestinal and cardiovascular symptoms, especially when linked to potential exposures. Early recognition and prompt management are critical for favorable outcomes.
(锡德树)因其药用和营养特性而被广泛使用,有文献记载其具有抗糖尿病、镇静和抗高血压等药理作用。然而,食用锡德树,尤其是在无监管的情况下,由于潜在毒性和农药污染,可能会带来重大健康风险。我们报告一例25岁男性病例,该患者在食用未清洗的水果后出现严重腹痛并放射至胸部、严重心动过缓(心率20多次)、低血压(收缩压50多次)及自主神经症状。初步检查发现莫氏I型二度房室传导阻滞、短暂性ST段压低及肌钙蛋白水平升高,这引发了对急性冠状动脉综合征(ACS)的怀疑。然而,包括CT冠状动脉造影和心脏磁共振成像在内的全面心脏评估排除了缺血性和结构性心脏病因。详细病史显示患者食用了未清洗的水果,提示农药暴露加剧了毒性。患者对包括阿托品在内的支持治疗反应良好,于第四天出院,症状完全缓解。该病例凸显了模仿ACS的有毒物质摄入所带来的诊断挑战。虽然尚不清楚高剂量时是否会诱发心脏毒性作用,但农药污染也可能导致了心脏毒性。临床医生在面对出现非典型胃肠道和心血管症状的患者时,应考虑毒理学病因,尤其是与潜在暴露相关的情况。早期识别和及时处理对于取得良好预后至关重要。