Doroudian Tehrani Maneli, Gibson Ruby S, Snyder Corey L, Porter Martina L, Kimball Alexa B
Clinical Laboratory for Epidemiology and Applied Research in Skin (CLEARS), Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Tulane University School of Medicine, New Orleans, Louisiana, USA.
J Eur Acad Dermatol Venereol. 2025 Aug;39(8):1395-1409. doi: 10.1111/jdv.20607. Epub 2025 Mar 11.
Hidradenitis suppurativa (HS) adversely affects quality of life, education, work, relationships and mental health. The debilitating effects of HS can compound over a patient's lifetime and have lasting repercussions. The cumulative life course impairment (CLCI) model analyses the disease factors that could affect the life course trajectory of a patient, including effects on major life decisions and opportunities, such as relationships, career path, education and starting a family. As with other diseases, direct longitudinal data for CLCI would require large long cohort studies. Nonetheless, the evidence supports that common domains delineated in the CLCI document impact that are consistent with the negative impact of HS on life course.
化脓性汗腺炎（HS）对生活质量、教育、工作、人际关系和心理健康产生不利影响。HS的衰弱作用会在患者一生中不断加剧，并产生持久影响。累积生命历程损伤（CLCI）模型分析了可能影响患者生命历程轨迹的疾病因素，包括对重大生活决策和机会的影响，如人际关系、职业道路、教育和组建家庭等。与其他疾病一样，CLCI的直接纵向数据需要大规模的长期队列研究。尽管如此，证据支持CLCI文件中所描述的常见领域的影响与HS对生命历程的负面影响相一致。
