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经耳道内镜下使用局部荧光素修复先天性内耳畸形继发的脑脊液耳漏

Transcanal Endoscopic Repair of Cerebrospinal Fluid Otorrhea Secondary to Congenital Inner Ear Anomaly Using Topical Fluorescein.

作者信息

Almalki Malak, Aloqailiy Yazeed, Nassar Jihad L, Alfirm Renad

机构信息

Otolaryngology and Head and Neck Surgery, King Abdulaziz Medical City, Riyadh, SAU.

Otolaryngology and Head and Neck Surgery, King Saud University, Riyadh, SAU.

出版信息

Cureus. 2025 Feb 8;17(2):e78738. doi: 10.7759/cureus.78738. eCollection 2025 Feb.

DOI:10.7759/cureus.78738
PMID:40065899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11893199/
Abstract

An eight-year-old female, known to have sensorineural hearing loss due to inner ear anomalies, presented with a history of recurrent attacks of right acute otitis media complicated by bacterial meningitis. Temporal bone computed tomography showed right middle ear and mastoid effusion without bony dehiscence or erosion, with features of common cavity inner ear anomaly on the right side. Given the patient's inner ear malformation, cerebrospinal fluid (CSF) otorrhea was suspected. Further evaluation with myringocentesis and beta trace protein analysis confirmed the diagnosis. The patient underwent transcanal endoscopic right ear exploration. Initially, the site of the defect was not revealed; the CSF leak was successfully localized at the oval window, surrounding the stapes footplate. This is the first report, to the best of our knowledge, describing topical fluorescein application in a transcanal endoscopic approach to obliterating CSF otorrhea due to inner ear malformation.

摘要

一名8岁女性,因内耳异常患有感音神经性听力损失,有复发性右急性中耳炎发作并并发细菌性脑膜炎的病史。颞骨计算机断层扫描显示右中耳和乳突积液,无骨质裂开或侵蚀,右侧具有共同腔型内耳异常的特征。鉴于患者的内耳畸形,怀疑有脑脊液耳漏。通过鼓膜穿刺和β-微球蛋白分析进行进一步评估确诊。患者接受了经耳道内镜右耳探查。最初,未发现缺损部位;脑脊液漏成功定位在卵圆窗,镫骨足板周围。据我们所知,这是第一份描述在经耳道内镜治疗内耳畸形所致脑脊液耳漏中应用局部荧光素的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/2fef4564b752/cureus-0017-00000078738-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/ca8d4da77962/cureus-0017-00000078738-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/20e77884edd2/cureus-0017-00000078738-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/d650e5872aac/cureus-0017-00000078738-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/2fef4564b752/cureus-0017-00000078738-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/ca8d4da77962/cureus-0017-00000078738-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/20e77884edd2/cureus-0017-00000078738-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/d650e5872aac/cureus-0017-00000078738-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a13/11893199/2fef4564b752/cureus-0017-00000078738-i04.jpg

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本文引用的文献

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Diagnosis and management of pediatric cerebrospinal fluid leakage secondary to inner ear malformations: A report of 13 cases.内耳畸形继发小儿脑脊液漏的诊断与处理:13例报告
Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110049. doi: 10.1016/j.ijporl.2020.110049. Epub 2020 Apr 13.
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Is topical fluorescein that effective in endoscopic CSF leak closure?局部荧光素在经内镜下脑脊液漏封闭中是否有效?
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Cerebrospinal fluid otorrhea secondary to congenital inner ear dysplasia: diagnosis and management of 18 cases.
先天性内耳发育不良致脑脊液耳漏 18 例诊治分析
J Zhejiang Univ Sci B. 2019;20(2):156-163. doi: 10.1631/jzus.B1800224.
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Long-term outcomes of a transmastoid lateral semicircular canal approach to congenital CSF otorrhea in children associated with recurrent meningitis and severe inner ear malformation.经乳突外侧半规管入路治疗儿童先天性脑脊液耳漏伴复发性脑膜炎和严重内耳畸形的长期疗效。
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Transcanal Endoscopic Management of Cerebrospinal Fluid Otorrhea Secondary to Congenital Inner Ear Malformations.先天性内耳畸形继发脑脊液耳漏的经耳道内镜治疗
Otol Neurotol. 2016 Jan;37(1):62-5. doi: 10.1097/MAO.0000000000000898.
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Lateral petrosectomy with obliteration cavity for spontaneous cerebrospinal otorrhea in children.小儿自发性脑脊液耳漏的岩骨外侧切除术及术腔填塞术
Am J Otolaryngol. 2014 Sep-Oct;35(5):651-4. doi: 10.1016/j.amjoto.2014.06.010. Epub 2014 Jul 2.
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Use of the translabyrinthine approach to repair congenital spontaneous cerebrospinal fluid leakage in five Chinese patients with Mondini dysplasia.
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Beyond the middle ear: endoscopic surgical anatomy and approaches to inner ear and lateral skull base.中耳之外:内耳及侧颅底的内镜手术解剖与入路
Otolaryngol Clin North Am. 2013 Apr;46(2):189-200. doi: 10.1016/j.otc.2012.12.001.
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Laryngoscope. 2012 Jun;122(6):1215-8. doi: 10.1002/lary.23277. Epub 2012 Mar 27.
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