Ducarme Morgane, Scaillet Jessika, De Cubber Mickaël, Chasse Emmanuel
Department of Endocrine Surgery, CH Epicura, Hornu 7301, Belgium.
Department of Thoracic Surgery, Erasme University Hospital, Brussels 1070, Belgium.
JCEM Case Rep. 2025 Mar 10;3(3):luaf043. doi: 10.1210/jcemcr/luaf043. eCollection 2025 Mar.
Amiodarone is a class III antiarrhythmic medication known for its complex interplay with thyroid physiology. Its prolonged half-life can result in persistent effects on thyroid function even after discontinuation. Amiodarone-induced thyrotoxicosis (AIT) is a serious and challenging complication due to these lasting effects. We present the cases of 2 patients who developed AIT resistant to standard medical treatment. Both patients required plasmapheresis sessions to reduce circulating levels of tetraiodothyronine (T4) prior to undergoing total thyroidectomy. Plasmapheresis is an effective intervention that significantly decreases circulating thyroid hormone levels, thereby lowering surgical risks associated with severe cardiac complications linked to thyrotoxicosis.
胺碘酮是一种III类抗心律失常药物，因其与甲状腺生理功能的复杂相互作用而闻名。其半衰期较长，即使停药后也会对甲状腺功能产生持续影响。由于这些持久的影响，胺碘酮诱发的甲状腺毒症（AIT）是一种严重且具有挑战性的并发症。我们报告了2例对标准药物治疗耐药的AIT患者病例。两名患者在接受甲状腺全切除术之前都需要进行血浆置换治疗，以降低血清四碘甲状腺原氨酸（T4）水平。血浆置换是一种有效的干预措施，可显著降低循环甲状腺激素水平，从而降低与甲状腺毒症相关的严重心脏并发症的手术风险。
