Ou Haiya, Lai Zhiming, Ye Xiaopeng, Wang Xiaotong, Lin Haixiong
Gastroenterology, Shenzhen Bao'an Traditional Chinese Medicine Hospital, China.
Gastroenterology, Shenzhen Bao'an Traditional Chinese Medicine Hospital.
Rev Esp Enferm Dig. 2025 Mar 11. doi: 10.17235/reed.2025.10983/2024.
The relationship between irritable bowel syndrome (IBS) and structural changes in various regional cortical areas remains unclear. Mendelian randomization (MR) was used to explore the potential association between IBS and Structural Brain Changes.
Genetically independent loci associated with IBS in individuals of European ancestry were selected as instrumental variants (IVs) in the large-scale genome-wide association studies (GWAS). Outcome data were obtained from 34 subregions of the cerebral cortex in a population of 51,665 individuals. MR analysis was performed to explore the potential association between IBS and cerebral cortex structure (surface area (SA) and thickness (TH)). Cochran's Q test, MR-Egger intercept test was used to examined heterogeneity and horizontal pleiotropy of single nucleotide polymorphisms (SNPs). "Leave-one-out" sensitivity analysis was conducted to assess the influence of individual SNPs.
Five relationships were obtained from a total of 68 phenotypes in 34 subregional structures of the cerebral cortex. IVW analysis showed that IBS was associated with increased SA in the inferior temporal and rostral anterior cingulate regions (βSA=22.810 mm2, PSA=0.040; βSA=11.133 mm2, PSA=0.006). Additionally, IBS was associated with increased TH in the isthmus cingulate and pars opercularis regions (βTH=0.013 mm, PTH=0.043; βTH=0.010 mm, PTH=0.010), and decreased TH in the rostral anterior cingulate region (βTH=-0.009 mm², PTH=0.017).
There is a potential association between IBS and the cerebral cortex structure. These findings provide important support for the association between diseases related to neurological damage and psychiatric abnormalities in IBS patients.
肠易激综合征（IBS）与各区域皮质结构变化之间的关系尚不清楚。采用孟德尔随机化（MR）方法探讨IBS与脑结构变化之间的潜在关联。
在大规模全基因组关联研究（GWAS）中，选择欧洲血统个体中与IBS相关的遗传独立位点作为工具变量（IVs）。从51665名个体的大脑皮质34个亚区域获取结局数据。进行MR分析以探讨IBS与大脑皮质结构（表面积（SA）和厚度（TH））之间的潜在关联。采用 Cochr an's Q检验、MR-Egger截距检验来检验单核苷酸多态性（SNP）的异质性和水平多效性。进行“留一法”敏感性分析以评估个体SNP的影响。
在大脑皮质34个亚区域结构的总共68种表型中获得了5种关联。IVW分析显示，IBS与颞下回和喙前扣带回区域的SA增加有关（βSA = 22.810 mm²，PSA = 0.040；βSA = 11.133 mm²，PSA = 0.006）。此外，IBS与扣带峡和岛盖部区域的TH增加有关（βTH = 0.013 mm，PTH = 0.043；βTH = 0.010 mm，PTH = 0.010），而与喙前扣带回区域的TH降低有关（βTH = -0.009 mm²，PTH = 0.017）。
IBS与大脑皮质结构之间存在潜在关联。这些发现为IBS患者中与神经损伤相关疾病和精神异常之间的关联提供了重要支持。
