Perkins Neil D
Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Sci Signal. 2025 Mar 11;18(877):eadv1265. doi: 10.1126/scisignal.adv1265.
The kinase IKKα phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of , Alonso-Marañón demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKKα complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance.
激酶IKKα使激酶ATM磷酸化，增强其促进DNA修复的能力。在本期杂志中，阿隆索 - 马拉尼翁等人证明，在结肠直肠癌细胞中，IKK调节亚基NEMO将ATM/IKKα复合物靶向DNA损伤位点，从而增强DNA修复和化疗耐药性。
