甲状腺癌代谢重编程：从机制到治疗策略

Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy.

作者信息

Wan Yuxuan, Li Guoqing, Cui Gaoyuan, Duan Saili, Chang Shi

机构信息

Department of General Surgery, Xiangya Hospital Central South University, Changsha, 410008, Hunan, People's Republic of China.

Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, People's Republic of China.

出版信息

Mol Cancer. 2025 Mar 11;24(1):74. doi: 10.1186/s12943-025-02263-4.

DOI:10.1186/s12943-025-02263-4

PMID:40069775

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11895238/

Abstract

Thyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment. In this review, we initiatively summarize recent progress in the full-scale thyroid cancer metabolic rewiring and the interconnection of various metabolites. We also discuss the efficacy and prospect of metabolic targeted detection as well as therapy. Comprehending metabolic mechanism and characteristics of thyroid cancer roundly will be highly beneficial to managing individual patients.

摘要

甲状腺癌作为内分泌系统最常见的恶性肿瘤之一，已引起公众关注并促使人们对其发病机制和治疗方法展开更多研究。基于代谢的疗法发展迅速，因为甲状腺癌具有独特的代谢特征。在甲状腺癌细胞中，大量代谢途径被重新编程以适应肿瘤微环境。在这篇综述中，我们主动总结了甲状腺癌全面代谢重塑以及各种代谢物之间相互联系的最新进展。我们还讨论了代谢靶向检测和治疗的疗效及前景。全面了解甲状腺癌的代谢机制和特征将对个体患者的管理大有裨益。