Zheng Hengyu, Cai Lina, Wang Pingrong, Zheng Lijiang, Lin Jiajia, Sun Ting, Li Jiaqi, Zuo Juntao, Liu Yuxiu, Ye Xianghong
Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Department of Critical Care Medicine, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
Nurs Crit Care. 2025 Mar;30(2):e70006. doi: 10.1111/nicc.70006.
Malnutrition due to interruption of enteral nutrition remains a prevalent issue in the intensive care unit (ICU).
This study aimed to determine the frequency and causes of enteral nutrition interruption (ENI)and its impact on implementing enteral nutrition.
This is a secondary analysis of a multicentre, cluster-randomized controlled trial (N = 2772). This secondary analysis included patients in the ICU for at least 72 h and receiving total enteral nutrition. The causes of ENI were defined as (1) feeding intolerance, (2) diagnostic and therapeutic procedures and (3) others. Multiple linear regression analyses investigated the association between ENI and nutrition intake.
A total of 1331 patients were included for analysis. Approximately 18.63% of the patients experienced at least one episode of ENI. The main cause of ENI was diagnostic and therapeutic procedures. Energy intake was 17.54 ± 6.85 versus 16.64 ± 7.06 (p = .065) among patients with and without ENI, and the protein intake was 0.69 ± 0.27 versus 0.64 ± 0.27 (p = .016). Multiple linear regression analysis revealed that ENI was significantly associated with diminishing energy and protein intake (B = -1.012, 95% CI -1.857 to -0.167, p = .019; B = -0.050, 95% CI -0.083 to -0.017, p = .003, respectively).
Based on this multicentre study about ENI, the incidence of interruptions in enteral nutrition was 18.6%, with diagnostic and therapeutic procedures being the leading causes. The occurrence of interruptions in the delivery of enteral nutrition leads to a reduction in the nutritional intake of critically ill patients.
Critical care nurses should establish comprehensive nutrition support protocols and strengthen the training of department nurses, equipping them with the skills to effectively prevent and manage ENI. This is essential for actively achieving feeding goals and improving the outcomes of ICU patients.
在重症监护病房（ICU）中，因肠内营养中断导致的营养不良仍然是一个普遍存在的问题。
本研究旨在确定肠内营养中断（ENI）的频率和原因及其对实施肠内营养的影响。
这是一项对多中心、整群随机对照试验（N = 2772）的二次分析。该二次分析纳入了在ICU住院至少72小时且接受全肠内营养的患者。ENI的原因定义为：（1）喂养不耐受，（2）诊断和治疗操作，以及（3）其他。多元线性回归分析研究了ENI与营养摄入之间的关联。
共纳入1331例患者进行分析。约18.63%的患者经历过至少一次ENI。ENI的主要原因是诊断和治疗操作。有ENI和无ENI的患者能量摄入量分别为17.54±6.85和16.64±7.06（p = 0.065），蛋白质摄入量分别为0.69±0.27和0.64±0.27（p = 0.016）。多元线性回归分析显示，ENI与能量和蛋白质摄入量减少显著相关（B = -1.012，95%CI -1.857至-0.167，p = 0.019；B = -0.050，95%CI -0.083至-0.017，p = 0.003）。
基于这项关于ENI的多中心研究，肠内营养中断的发生率为18.6%，诊断和治疗操作是主要原因。肠内营养输送中断的发生导致重症患者营养摄入减少。
重症护理护士应制定全面的营养支持方案，加强科室护士培训，使他们具备有效预防和管理ENI所需的技能。这对于积极实现喂养目标和改善ICU患者的预后至关重要。
