Mendes-Pinto Daniel, Melo Larissa Jardim, Costa Guilherme Galvone Fonseca, Santos Izabella Campolina, Silva Ana Paula Pires, de Avelar Roberto Lucas Senna, de Castro-Santos Guilherme, Rodrigues-Machado Maria da Glória
Hospital Felício Rocho, Belo Horizonte, MG, Brasil.
Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.
J Vasc Bras. 2025 Feb 24;24:e20230049. doi: 10.1590/1677-5449.202300492. eCollection 2025.
Pedal acceleration time (PAT) is a novel indicator of peripheral arterial disease in the lower limbs. Elevated PAT values are associated with worse limb ischemia. Arterial stiffness indexes are another class of indicators recently studied in patients with chronic limb-threatening ischemia (CLTI). The correlation between PAT and arterial stiffness has not yet been established.
To analyze correlations between PAT and arterial stiffness indexes in patients with CLTI.
A cross-sectional analysis was conducted of patients with CLTI from August to December of 2022. The PAT measurements were performed using a vascular ultrasound machine and stiffness indexes were measured using a brachial artery oscillometry unit. An analysis was conducted of the correlations between central blood pressure, peripheral blood pressure, arterial stiffness, and PAT.
A total of 55 patients were analyzed, of whom 23 were women and 83.6% had diabetes. Mean PAT was 166.6 ms; mean pulse wave velocity (PWV) was 11.8 m/s, and the mean augmentation index corrected for a heart rate of 75 beats per minute (AIx@75) was 29.8%. There were positive correlations between PAT and PWV (Spearman r = 0.69; p < 0.001) and between PAT and AIx@75 (Spearman r = 0.59, p < 0.001) and an inverse relationship with the ankle/brachial index (Spearman r = -0.79; p < 0.001).
There is a correlation between arterial stiffness indexes and PAT in patients with CLTI. These indicators are important for quantification of limb ischemia.
踏板加速时间（PAT）是下肢外周动脉疾病的一项新指标。PAT值升高与更严重的肢体缺血相关。动脉僵硬度指数是最近在慢性肢体威胁性缺血（CLTI）患者中研究的另一类指标。PAT与动脉僵硬度之间的相关性尚未确立。
分析CLTI患者中PAT与动脉僵硬度指数之间的相关性。
对2022年8月至12月的CLTI患者进行横断面分析。使用血管超声仪测量PAT，使用肱动脉示波测量仪测量僵硬度指数。对中心血压、外周血压、动脉僵硬度和PAT之间的相关性进行分析。
共分析了55例患者，其中23例为女性，83.6%患有糖尿病。平均PAT为166.6毫秒；平均脉搏波速度（PWV）为11.8米/秒，心率为每分钟75次时校正的平均增强指数（AIx@75）为29.8%。PAT与PWV之间存在正相关（斯皮尔曼r = 0.69；p < 0.001），PAT与AIx@75之间存在正相关（斯皮尔曼r = 0.59，p < 0.001），与踝肱指数呈负相关（斯皮尔曼r = -0.79；p < 0.001）。
CLTI患者的动脉僵硬度指数与PAT之间存在相关性。这些指标对于量化肢体缺血很重要。
