Yao Ying, Chen Yuanzheng, Fu Jie, Ding Jinsong, Zhou Wenhu, Chen Xinyi, Wan Xiuping
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
Yongkang First People's Hospital of Wenzhou Medical University, Jinhua, 321300, China.
Mater Today Bio. 2025 Feb 20;31:101598. doi: 10.1016/j.mtbio.2025.101598. eCollection 2025 Apr.
Iron deficiency anemia (IDA) is a global health concern, particularly affecting women and children of reproductive age. Although oral iron supplements are the standard treatment for IDA, their bioavailability is often compromised by food interactions, and they are associated with significant gastrointestinal side effects. To overcome these limitations, we developed a novel iron nano-supplement, TA-Fe NPs, based on metal-polyphenol networks (MPNs) formed through the coordination of tannic acid (TA) and Fe. These uniform nanoparticles (∼190 nm) offer enhanced chemical stability and reduced food interference compared to traditional iron supplements. The polyphenolic TA component provides antioxidant properties, effectively mitigating oxidative stress and inflammation induced by free iron ions. To further improve stability and intestinal absorption, TA-Fe NPs were encapsulated in an enteric coating (TA-Fe@L100) to protect against acidic conditions in the stomach. In a mouse model of IDA, TA-Fe@L100 demonstrated superior therapeutic efficacy compared to FeSO, including improvements in hematological parameters, organ iron storage, and gut microbiota balance. Importantly, TA-Fe@L100 alleviated common gastrointestinal side effects associated with iron supplementation, presenting a promising alternative for IDA treatment. Our findings suggest that TA-Fe@L100 is a cost-effective and biocompatible oral iron supplement with minimal side effects, offering significant potential for broader clinical application in the management of IDA.
缺铁性贫血（IDA）是一个全球性的健康问题，尤其影响育龄妇女和儿童。尽管口服铁补充剂是治疗IDA的标准方法，但其生物利用度常因食物相互作用而受到影响，并且它们还伴有严重的胃肠道副作用。为了克服这些局限性，我们基于通过单宁酸（TA）与铁配位形成的金属-多酚网络（MPN）开发了一种新型铁纳米补充剂TA-Fe NPs。与传统铁补充剂相比，这些均匀的纳米颗粒（约190纳米）具有更高的化学稳定性和更低的食物干扰性。多酚类TA成分具有抗氧化特性，可有效减轻游离铁离子诱导的氧化应激和炎症。为了进一步提高稳定性和肠道吸收，TA-Fe NPs被包裹在肠溶衣中（TA-Fe@L100）以抵御胃中的酸性环境。在IDA小鼠模型中，TA-Fe@L100显示出比硫酸亚铁更好的治疗效果，包括血液学参数、器官铁储存和肠道微生物群平衡的改善。重要的是，TA-Fe@L100减轻了与铁补充相关的常见胃肠道副作用，为IDA治疗提供了一种有前景的替代方案。我们的研究结果表明，TA-Fe@L100是一种经济有效且生物相容性良好的口服铁补充剂，副作用极小，在IDA管理中具有广阔的临床应用潜力。
