Fang Jintao, Zhu Weihan, Yu Dian, Zhu Lujian, Zha Haorui, Tang Jingyi, Li Yujia, Zhu Xiaxin, Zhao Ting, Zhang Wei
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, People's Republic of China.
Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua, 321000, People's Republic of China.
J Inflamm Res. 2025 Mar 7;18:3349-3360. doi: 10.2147/JIR.S498703. eCollection 2025.
Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation of Gasdermin proteins, which form membrane pores, leading to rapid cell rupture and the release of inflammatory molecules. Unlike other types of cell death, pyroptosis has distinct activation mechanisms and plays a complex role in chronic intestinal diseases, including inflammatory bowel disease, intestinal fibrosis, chronic infectious enteritis, and colorectal cancer. This review comprehensively examines how pyroptosis influences disease development and progression while exploring the therapeutic potential of targeting pyroptosis-related pathways. Moreover, the complex interplay between gut microbiota and pyroptosis is summarized, highlighting its critical role in the pathogenesis of chronic intestinal disorders. A deeper understanding of pyroptosis-related mechanisms in these diseases may provide valuable insights for future research and contribute to the development of innovative therapeutic strategies in gastroenterology.
细胞焦亡是一种独特的程序性细胞死亡形式，其特征是强烈的炎症反应。它涉及Gasdermin蛋白的激活，该蛋白形成膜孔，导致细胞迅速破裂并释放炎症分子。与其他类型的细胞死亡不同，细胞焦亡具有独特的激活机制，并且在慢性肠道疾病（包括炎症性肠病、肠道纤维化、慢性感染性肠炎和结直肠癌）中发挥复杂作用。本综述全面研究了细胞焦亡如何影响疾病的发展和进程，同时探索了靶向细胞焦亡相关途径的治疗潜力。此外，总结了肠道微生物群与细胞焦亡之间的复杂相互作用，突出了其在慢性肠道疾病发病机制中的关键作用。深入了解这些疾病中与细胞焦亡相关的机制可能为未来研究提供有价值的见解，并有助于胃肠病学创新治疗策略的开发。
